{"created":"2023-07-25T08:06:05.207333+00:00","id":4738,"links":{},"metadata":{"_buckets":{"deposit":"b27fb5f3-fa8c-48f7-afb2-4d7734d0fcd1"},"_deposit":{"created_by":3,"id":"4738","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4738"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00004738","sets":["228:230:5179","57:86"]},"author_link":["125473"],"control_number":"4738","item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"76","bibliographicPageStart":"67","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical journal of Kagoshima University","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1995-03-14","subitem_date_issued_type":"Issued"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"1995-03-14"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"(Purpose) The effect of CDP-choline intrathecal administralion on Mongolian gerbil's forebrain ischemia was analyzed on the basis of time-courses of blood flow and EEG and of pathological findings. (Methods) First， as a preliminary experiment， the effect of and optimal drug concentration for the above intrathecal administration were examined. As a result. excessive intrathecal administration of CDP-choline was confirmed to cause spasmogenicity，thus 5μl (20mg/kg) was used as dose of administlation. The experiment was performed under spontaneous respiration with a cannula being indwelled intracisternally. While loading with forebrain ischemia for 10 minutes，cerebral blood flow and EEG were recorded， and a group of pre-loading intrathecal administration of physiological saline (n=2) were prepared. For both groups， pathological specimens were prepared after cerebral perfusion and fixation on day 7.\n(Results) No significant difference in cerebral blood flow and EEG was noted between both groups. Pathohlstologically， the CDP-choling-given group showed a tendency to slighter neurocytonecrosis. (Discussion) CDP-choline has already been shown to be an important co-enzyme for the metabolism of phospholipid， main constitutive component of cell membrane. The recognized effect of CDP-choline adminislered intrathecally can be interpreted as such that the effect of CDP-choline on cell membranous phospholipid causes inhibition of an increase in free fatty acid and of the generation of lipid peroxide and free radical generating in a series of subsequent metabolic processes，on one hand and the retention of mitochondrial function causes inhibition of an increase in intracellular Ca and of subsequent decomposition of structural protein following re-opening on the other.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"医歯学総合研究科博士論文(医学) ; 学位取得日: 平成7年3月14日","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3083026","subitem_identifier_reg_type":"JaLC"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_5_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://id.ndl.go.jp/bib/000000286354","subitem_relation_type_select":"URI"}}]},"item_5_relation_33":{"attribute_name":"関連（isVersionOf）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dl.ndl.go.jp/info:ndljp/pid/3083026","subitem_relation_type_select":"URI"}}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0368-5063","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"平成22年度に行われた国立国会図書館の学位論文（博士）デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用（全文複写提供、公衆送信）に供することの許諾を受けたものです（参考：http://www.ndl.go.jp/jp/aboutus/digitization_theses.html）。"}]},"item_5_text_52":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"医論第1036号"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"増田, 次俊","creatorNameLang":"ja"},{"creatorName":"マスダ, ツギトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Masuda, Tsugitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125473","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"000000286354.pdf","filesize":[{"value":"8.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000286354.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/4738/files/000000286354.pdf"},"version_id":"3fcb4892-58bb-4915-a57d-e8413998db29"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CDP-choline","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebral ischemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"delayed neuronal death","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intrathecal administration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"CDP-cholineの砂ネズミ虚血脳における細胞障害への治療的効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CDP-cholineの砂ネズミ虚血脳における細胞障害への治療的効果","subitem_title_language":"ja"},{"subitem_title":"An Experimental Study on the Therapeutic Effects of CDP-Choline on Neuronal Damages in the Cerebral Ischemia of Mongolian Gerbils","subitem_title_language":"en"},{"subitem_title":"CDP-choline ノ スナネズミ キョケツノウ ニオケル サイボウ ショウガイ エノ チリョウ コウカ","subitem_title_language":"ja-Kana"}]},"item_type_id":"5","owner":"3","path":["5179","86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-04-30"},"publish_date":"2015-04-30","publish_status":"0","recid":"4738","relation_version_is_last":true,"title":["CDP-cholineの砂ネズミ虚血脳における細胞障害への治療的効果"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-01-09T05:10:11.711657+00:00"}