{"created":"2023-07-25T08:06:20.161823+00:00","id":5062,"links":{},"metadata":{"_buckets":{"deposit":"06d28ce6-63e0-4621-87b5-11b239536904"},"_deposit":{"created_by":3,"id":"5062","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5062"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005062","sets":["228:230:5165","57:58:59"]},"author_link":["119470","119444","119476","119442","119448","119480","119468","119443","119445","119477","119475","119438","119479","119471","119482","119446","119472","119440","119478","119481","119441","119439","119469","119451","119447","119449","119473","119450","119474","119452"],"item_7_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"肝細胞癌におけるHigh mobility group box-1（HMGB1）発現の意義"}]},"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueNumber":"3","bibliographicPageEnd":"35","bibliographicPageStart":"27","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌=Medical journal of Kagoshima University"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-01-01"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: High mobility group box-1 (HMGB1) induces the release of proinflammatory cytokines and chemokines\nas a late-acting mediator of inflammation. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer,\nhowever, little is known about the relationship between HCC and HMGB1 and its receptor RAGE (receptor for advanced\nglycation end products). We studied the clinicopathological relevance of the expression level of HMGB1 and the effect of\nHMGB1 expression on the characteristics of HCC.\nMethods: Samples from the 36 HCC patients including 7 with positive hepatitis B surface antigen and 21 with hepatitis\nC antibody were studied. Twenty-four patients had chronic active hepatitis and 4 had liver cirrhosis. The expression of\nHMGB1 was assessed in paired cancerous and noncancerous tissues with HCC, using reverse-transcription polymerase\nchain reaction (RT-PCR), and Western blotting. Quantitative RT-PCR data were analyzed relation to clinicopathological\nfeatures. As a control study, 7 normal liver samples were collected from patients other than HCC. Results: The expression of HMGB1 mRNA was lower in normal liver than in noncancerous tissue and the highest\nin HCC, although the differences were not significant. Furthermore, in HCC, it was high in well- and moderately\ndifferentiated tumors but declined as tumors dedifferentiated to poorly differentiated HCC (p=0.033). The expression\nlevel was inversely correlated with tumor recurrence (p=0.036). No significant correlations were observed between the\nexpression levels and well-known prognostic factors of HCC (e.g. portal invasion and intrahepatic metastasis).\nConclusion: In HCC, HMGB1 expression level correlated inversely with the patient’s prognosis. The HMGB1 mRNA\nexpression level is similar to the level we reported previously in a study on the clinicopathological relevance of the level of\nRAGE in HCC. RAGE-HMGB1 interaction in HCC might work in the early stage of tumorigenesis more than in the stage of\ncancer development.","subitem_description_type":"Other"}]},"item_7_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"上野, 真一"}]},{"nameIdentifiers":[{}],"names":[{"name":"樋渡, 清司"}]},{"nameIdentifiers":[{}],"names":[{"name":"迫田, 雅彦"}]},{"nameIdentifiers":[{}],"names":[{"name":"飯野, 聡"}]},{"nameIdentifiers":[{}],"names":[{"name":"蔵原, 弘"}]},{"nameIdentifiers":[{}],"names":[{"name":"南, 幸次"}]},{"nameIdentifiers":[{}],"names":[{"name":"安藤, 慶"}]},{"nameIdentifiers":[{}],"names":[{"name":"前村, 公成"}]},{"nameIdentifiers":[{}],"names":[{"name":"又木, 雄弘"}]},{"nameIdentifiers":[{}],"names":[{"name":"松本, 正隆"}]},{"nameIdentifiers":[{}],"names":[{"name":"大脇, 哲弘"}]},{"nameIdentifiers":[{}],"names":[{"name":"北薗, 正樹"}]},{"nameIdentifiers":[{}],"names":[{"name":"石神, 純也"}]},{"nameIdentifiers":[{}],"names":[{"name":"新地, 洋之"}]},{"nameIdentifiers":[{}],"names":[{"name":"夏越, 祥次"}]}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03685063","subitem_source_identifier_type":"ISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_7_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_7_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"UENO, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIWATASHI, Kiyokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKODA, Masahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IINO, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KURAHARA, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MINAMI, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ANDO, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MAEMURA, Kosei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATAKI, Yukou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUMOTO, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OWAKI, Tetsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KITAZONO, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIGAMI, Sumiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHINCHI, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NATSUGOE, Shoji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"AN00040104_v62n3_p27-35.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00040104_v62n3_p27-35.pdf","url":"https://ir.kagoshima-u.ac.jp/record/5062/files/AN00040104_v62n3_p27-35.pdf"},"version_id":"e07c0b00-fa81-4690-96bd-c23b8834dcf2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatocellular carcinoma (HCC)","subitem_subject_scheme":"Other"},{"subitem_subject":"high mobility group box-1 (HMGB1)","subitem_subject_scheme":"Other"},{"subitem_subject":"reverse transcription-polymerase chain reaction (RT - PCR)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Significance of High Mobility Group Box-1 (HMGB1) Expression in Hepatocellular Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significance of High Mobility Group Box-1 (HMGB1) Expression in Hepatocellular Carcinoma"}]},"item_type_id":"7","owner":"3","path":["59","5165"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-03"},"publish_date":"2012-07-03","publish_status":"0","recid":"5062","relation_version_is_last":true,"title":["Significance of High Mobility Group Box-1 (HMGB1) Expression in Hepatocellular Carcinoma"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-01T11:23:10.008046+00:00"}