{"created":"2023-07-25T08:06:21.644815+00:00","id":5096,"links":{},"metadata":{"_buckets":{"deposit":"21df968c-3a30-449e-a002-a30b37c6ff32"},"_deposit":{"created_by":18,"id":"5096","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"5096"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005096","sets":["57:80"]},"author_link":["7040"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(B)))研究成果報告書　課題番号：21390059　研究代表者：亀山正樹 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Ｌ型CaチャネルのCaMおよびリン酸化による調節について検討した。CaMはチャネルＣ末部のpreIQとIQ領域に１分子ずつ結合した。PKAによるリン酸化部位は、既存のSer1927（モルモット）に加えて、Ser1574とSer1626とが新たに判明した。CaMKIIによるPreIQ領域にあるThr1603のリン酸化によりCaM作用が増強され、両調節機構の間にクロストークが存在することが判明した。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We investigated regulation of L-type Ca2+ channels by calmodulin (CaM) and phosphorylation. CaM bound to preIQ and IQ regions in the C-terminal of the channel. PKA phosphorylated Ser1574 and Ser1626 as well as Ser1927 (guinea-pig). The facilitatory effect of CaM was enhanced by CaMKII-mediated phosphorylation of Thr1603, suggesting a cross-talk between the CaM’s effect and channel phosphorylation.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21390059"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"亀山, 正樹","creatorNameLang":"ja"},{"creatorName":"KAMEYAMA, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7040","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060150059","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21390059seika.pdf","filesize":[{"value":"200.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21390059seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/5096/files/21390059seika.pdf"},"version_id":"6b049ad1-9ca5-426b-8cc5-98ed20b978c3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"生体膜","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"チャネル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心筋Caチャネルの調節機構間相互作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心筋Caチャネルの調節機構間相互作用","subitem_title_language":"ja"},{"subitem_title":"An interrelation among regulatory mechanisms of cardiac Ca2+ channels","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"5096","relation_version_is_last":true,"title":["心筋Caチャネルの調節機構間相互作用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:23:53.386272+00:00"}