{"created":"2023-07-25T08:06:22.122432+00:00","id":5107,"links":{},"metadata":{"_buckets":{"deposit":"51261b7d-2f81-481e-b7b5-2025cd8a8bc1"},"_deposit":{"created_by":18,"id":"5107","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"5107"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005107","sets":["57:80"]},"author_link":["24003"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21590905　研究代表者：濱崎秀一 (鹿児島大学大学院医歯学総合研究科准教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"慢性心筋炎から拡張型心筋症に移行するinflammatory cardiomyopathyという新たな心筋症概念の炎症活動性はTLR2値の高低でとらえられるという仮説を検証しようとしたが、明らかな相関関係は見いだせなかった。TLR2が拡張型心筋症の診断の際のマーカーとしての有用である可能性も検証しようとしたが、明らかな関連性はみとめられていない。しかしながら、心サルコイドーシスにおいては、TLR2は極めて高値を示し、診断のためのマーカーとしての有用である可能性が確認された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We hypothesized that Toll-like receptor 2 (TLR2) expression level on monocytes can be useful as a marker of inflammatory activity in inflammatory cardiomyopathy as a new concept which choronic myocarditis evolves to dilated cardiomyopathy. Thus, we tried to validate our hypothesis by comparing pathological findings of species derived from myocardium with TLR2 expression level on monocytes, but our trial ended up in failure. We could not either verify the usefulness of Toll-like receptor 2 expression level on monocytes for establishing the diagnostic criteria of dilated cardiomyopathy as an inflammatory cardiomyopathy. Although the patients who were diagnosed as cardiac sarcoidosis showed extremely higher level of TLR2, which may suggest that TLR2 expression level on monocytes is identified as a significant contributor for cardiac sarcoidosis. Therefore, high TLR2 expression level on monocytes may be an independent risk factor for cardiac sarcosidosis.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21590905"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濱崎, 秀一","creatorNameLang":"ja"},{"creatorName":"HAMASAKI, Shuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24003","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010315434","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21590905seika.pdf","filesize":[{"value":"308.6 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21590905seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/5107/files/21590905seika.pdf"},"version_id":"0f8e9d35-02a5-417e-904c-6f80f4577dfb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"臨床","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"内科","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"循環器","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"感染症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心筋症における単球膜上トールライクレセプター発現量の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心筋症における単球膜上トールライクレセプター発現量の検討","subitem_title_language":"ja"},{"subitem_title":"Toll-like receptor expression level on circulating monocyte in cardiomyopathy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"5107","relation_version_is_last":true,"title":["心筋症における単球膜上トールライクレセプター発現量の検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:23:56.024565+00:00"}