{"created":"2023-07-25T08:06:22.166757+00:00","id":5108,"links":{},"metadata":{"_buckets":{"deposit":"9781a1e8-ee11-449c-ab26-b31ce70bf94f"},"_deposit":{"created_by":18,"id":"5108","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"5108"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005108","sets":["57:80"]},"author_link":["25046"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-30","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21591367　研究代表者：河野嘉文 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"ヒト造血幹細胞の加齢現象を検討するため、２つの細胞転写因子の発現量を検討した。中央値21歳の移植ドナー細胞をCD34陽性細胞に純化し、純度90％以上の細胞分画を得た。それらの細胞の転写因子ikzf1とcebpaの発現量を定量的に測定し、ikzf1の発現量とドナーの年齢の間に負の相関関係があることが判明した。一方、cebpaの発現量はドナー年齢と関係しなかった。これらの結果から、CD34陽性細胞内のikzf1のmRNAレベルは骨髄内のヒト造血幹細胞の年齢を反映していると考えられた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"To investigate aging of human hematopoietic stem cells, we evaluated the expression levels The median age of the donors was 21 y (range 0.2 – 44 y). The purity of CD34-positive cells was greater than 90%. Both target genes were quantitatively detected in all samples. There was an inverse correlation between the expression level of ikzf1 and the donor's age (r = -0.358, p = 0.032). In contrast, there was no correlation between the expression level of cebpa and the donor's age. From the  data, the mRNA level of ikzf1 in purified CD34-positive cells may reflect the age of HSCs in human bone marrow.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21591367"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 嘉文","creatorNameLang":"ja"},{"creatorName":"KAWANO, Yoshifumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"25046","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020260680","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21591367seika.pdf","filesize":[{"value":"693.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21591367seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/5108/files/21591367seika.pdf"},"version_id":"383a90fc-5a40-422a-9916-ef08282d8ddc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"造血幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"造血幹細胞移植","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CD34陽性細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"加齢","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"老化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"転写因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト造血幹細胞の加齢に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト造血幹細胞の加齢に関する研究","subitem_title_language":"ja"},{"subitem_title":"Research on aging of human hematopoietic stem cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"5108","relation_version_is_last":true,"title":["ヒト造血幹細胞の加齢に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:23:57.076921+00:00"}