{"created":"2023-07-25T08:06:22.210671+00:00","id":5109,"links":{},"metadata":{"_buckets":{"deposit":"df010824-bac7-43db-b04c-c567657bdcb8"},"_deposit":{"created_by":3,"id":"5109","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5109"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005109","sets":[]},"author_link":["117914","117913","2111"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of new therapeutic strategy for skin cancers targeting CD147/Basigin"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"CD147/Basigin オ ヒョウテキ トシタ アラタナ ヒフガン チリョウ センリャク ノ コウチク"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-04-19"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21591438　研究代表者：金蔵拓郎 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_type":"Other"},{"subitem_description":"我々は本研究で細胞膜分子CD147/basiginは悪性黒色腫細胞の解糖系を制御することで増殖、浸潤、転移を促進すること、また細胞膜上でintegrinと共存し、その下流のfocal adhesion kinase (FAK)のリン酸化を介して基質に対する接着更には局所浸潤を制御していることを明らかにした。これらの知見はCD147/basiginが皮膚癌治療の標的分子となり得ることを示している。","subitem_description_type":"Other"},{"subitem_description":"We revealed that CD147/basigin promotes proliferation, invasion, and metastasis of malignant melanoma through regulating tumor cell glycolysis and regulates tumor cell adhesion to matrix through phosphorylating the focal adhesion kinase (FAK), a downstream kinase of integrin that co-localizes with CD147 on the cell surface. These findings demonstrate that CD147/basigin could be a target molecule for new therapeutic strategy for skin cancers.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"カネクラ, タクロウ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"KANEKURA, Takuro"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21591438"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金蔵, 拓郎"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21591438seika.pdf","filesize":[{"value":"226.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21591438seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/5109/files/21591438seika.pdf"},"version_id":"2c81e281-4ab2-4312-b3c7-2b1185ec4463"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD147/Basigin","subitem_subject_scheme":"Other"},{"subitem_subject":"皮膚癌","subitem_subject_scheme":"Other"},{"subitem_subject":"治療","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"CD147/Basiginを標的とした新たな皮膚癌治療戦略の構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CD147/Basiginを標的とした新たな皮膚癌治療戦略の構築"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"5109","relation_version_is_last":true,"title":["CD147/Basiginを標的とした新たな皮膚癌治療戦略の構築"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:43.725319+00:00"}