{"created":"2023-07-25T08:06:22.568359+00:00","id":5117,"links":{},"metadata":{"_buckets":{"deposit":"90c8e4dd-6948-4961-9404-cb72f9313b2b"},"_deposit":{"created_by":18,"id":"5117","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"5117"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005117","sets":["54:79"]},"author_link":["25070"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-29","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書　課題番号：22790435　研究代表者：橋口周平 (鹿児島大学大学院理工学研究科(工学系)助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"βシート構造にリフォールディングされたヒト組み換えプリオン蛋白だけに反応し、正常な構造のプリオン蛋白には結合しないPRB7 IgG抗体を作製し、128–132の領域に弱い相同性のあるミモトープペプチドを単離した。バクテリオファージは私どもの生活環境に常在する、細菌に感染するウィルスであるが、アジュバントを用いることなく強いIgG抗体応答を誘導できることから、プリオン抗体のミモトープを提示したファージは治療抗体を誘導できるワクチンに応用できると考えられる。バクテリオファージは、安価に短期間で大量調整が可能であり、安全なワクチン担体として利用できると考えられる。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Phage display library is powerful tool to develop various recombinant peptides or human antibodies applicable for revolutionary therapeutics. In addition to this feature, peptide-displaying phage clones induce mimotope-specific antibody responses in mice. In this study, we have established a human IgG1 antibody specific to β-form prion protein (PrP) but not to α-form PrP, PRB7 IgG. Employing a peptide-displaying phage library, the mimotope was determined to be at #128-132 of human PrP. A single injection of peptide-displaying phage stimulate innate immune response and elicited a strong IgG response in mice, suggests a possible application of peptide-displaying phage clones as vaccine carriers for induction of therapeutic antibodies.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"22790435"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"橋口, 周平","creatorNameLang":"ja"},{"creatorName":"HASHIGUCHI, Shuhei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"25070","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040295275","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"22790435seika.pdf","filesize":[{"value":"213.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"22790435seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/5117/files/22790435seika.pdf"},"version_id":"8f57c780-3a6b-4203-8565-1f4ffa80a868"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バクテリオファージ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ワクチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自然免疫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"プリオン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ファージディスプレイ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プリオン抗原をディスプレイするファージワクチンによる自己抗体の誘導と免疫制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プリオン抗原をディスプレイするファージワクチンによる自己抗体の誘導と免疫制御","subitem_title_language":"ja"},{"subitem_title":"M13 bacteriophage-based vaccine design for prion","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["79"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"5117","relation_version_is_last":true,"title":["プリオン抗原をディスプレイするファージワクチンによる自己抗体の誘導と免疫制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-23T02:18:17.478304+00:00"}