{"created":"2023-07-25T08:06:26.284697+00:00","id":5202,"links":{},"metadata":{"_buckets":{"deposit":"436df8dc-de6b-48f6-9519-e071fcf6618d"},"_deposit":{"created_by":3,"id":"5202","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5202"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005202","sets":["228:256:5407","31:32:93:94"]},"author_link":["110031","110029","110030","110028","25429","110032"],"item_7_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Hepatic Cancer of Rats Induced by Cycasin"}]},"item_7_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ソテツ シュシ ガンユウ ハイトウタイ (Cycasin) ニヨル ジッケンテキ カンガン"}]},"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicPageEnd":"23","bibliographicPageStart":"1","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"南方海域調査研究報告=Occasional Papers"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1986-03-20"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Although the seeds of cycad plants have been used as a food in southern areas in\nJapan, people have known that it was toxic without adequate removal of the toxin.\nThe toxin in Japanese Cycas revoluta Thunb. was isolated and the structure of the\ntoxin was elucidated as Cycasin, methylazoxymethyl - β - D-glucoside, by Nishida, Kobayashi and Nagahama in 1955.\nLaqueur et al. (1963) found that the cycad seeds in Guam had carcinogenic actions in experimental animals through his studies about persumed relationship between\ningestion of cycad seeds and neurogenic disorders in men and cattle.\nThe results of many studies indicated that the toxicity and the carcinogenicity\nof Cycasin were revealed after the enzymatic hydrolysis of Cycasin to the aglycon\n(Methylazoxymethanol) and that this conversion was brought about in vivo by the\naction of β -glucosidase, most likely of intestinal bacterial origin.\nStudies about carcinogenic action of Cycasin and morphological studies on hepatic\ncancer were carried out in two age-groups of Sprague-Dawley strain rats induced\ngiven 10mg/kg body weight of Cycasin in drinking water through experimental periods.\nFourteen cases each of hepatic cancer were observed in both sexes (17 females and\n16 males) in 21-day-old group of animals between 167 and 487 experimental days in\nfemale rats, and between 203 and 438 in male rats. In 50-day-old (20 rats each in\nboth sexes), 18 each of hepatic cancer were observed between 251 and 556 in female\nrats, and between 280 and 556 in male rats.\nMacroscopic findings of hepatic tumors were graysh-white nodules with focal hemorrhagic lesions. Macroscopically, most of hapatoma were composed of well differentiated type of hepatocellular carcinoma with trabecular pattern of the tumor cells.\nAnd clear cell type of adenocarcinoma, intestinal metalasia type of cancer and pleomorphic cell carcinoma were also observed, but these types of cancer were rare cases.\nSome cases had sarcomatous pattern of tumor growth. Only one case had liver cirrhotic changes with well differentiated type of hepatoma.\nElectronmicroscopic findings of tumor cell, such as peroxsomes, tight junctions\nand bile ductlesses between the tumor cells, suggested that most of the tumor were\nhepatic cell origin.","subitem_description_type":"Other"},{"subitem_description":"小林昭（鹿児島大学農学部農芸化学科）","subitem_description_type":"Other"},{"subitem_description":"寺師慎一（鹿児島大学南方海域研究センター）","subitem_description_type":"Other"}]},"item_7_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"コバヤシ, アキラ"}]},{"nameIdentifiers":[{}],"names":[{"name":"テラシ, シンイチ"}]}]},"item_7_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"KOBAYASHI, Akira"}]},{"nameIdentifiers":[{}],"names":[{"name":"TERASHI, Shin-ichi"}]}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_7_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15898"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15899"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15900"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15901"}]}]},"item_7_relation_33":{"attribute_name":"関連（isVersionOf）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10232/15897","subitem_relation_type_select":"URI"}}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02892707","subitem_source_identifier_type":"ISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10030752","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_7_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_7_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_7_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"Title page: http://hdl.handle.net/10232/15897, 序文: http://hdl.handle.net/10232/15898, 開会の辞: http://hdl.handle.net/10232/15899, 主旨説明: http://hdl.handle.net/10232/15900, 目次: http://hdl.handle.net/10232/15901"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺師, 慎一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"AN10030752_v6_p1-23.pdf","filesize":[{"value":"10.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10030752_v6_p1-23.pdf","url":"https://ir.kagoshima-u.ac.jp/record/5202/files/AN10030752_v6_p1-23.pdf"},"version_id":"9d28eb12-18ea-494d-8af8-0026413f10aa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ソテツ種子含有配糖体(Cycasin)による実験的肝癌","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ソテツ種子含有配糖体(Cycasin)による実験的肝癌"}]},"item_type_id":"7","owner":"3","path":["94","5407"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-08"},"publish_date":"2015-06-08","publish_status":"0","recid":"5202","relation_version_is_last":true,"title":["ソテツ種子含有配糖体(Cycasin)による実験的肝癌"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-12T06:36:29.792098+00:00"}