{"created":"2023-07-25T08:06:26.327625+00:00","id":5203,"links":{},"metadata":{"_buckets":{"deposit":"c1822573-6af7-4320-933f-53a2c5abab04"},"_deposit":{"created_by":3,"id":"5203","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5203"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005203","sets":["228:256:5407","31:32:93:94"]},"author_link":["110034","110033","110035"],"item_7_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Hepatitis Viruses and Liver Diseases"}]},"item_7_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ウイルスセイ カンエン ノ エキガク, リンショウ ト ビョウリ"}]},"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicPageEnd":"47","bibliographicPageStart":"25","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"南方海域調査研究報告=Occasional Papers"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1986-03-20"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Viral hepatitis of human being is caused by the various types of hepatitis\nviruses, such as hepatitis A virus, B virus, δ virus and unknown non-A, non-B\nhepatitis viruses. Although those viruses belong respectivelly different virus\ngroups, (some one is RNA virus and the other one is DNA virus) the clinical\nsymptoms and histological features of the liver of each viral hepatitis are quite\nsimilar.\nHowever, there is some difference among liver diseases caused by each virus.\nHepatitis A virus and Indian type non-A, non-B virus only cause acute hepatitis\nby transient infection. On the contrary, hepatitis B virus and other non-A, non-B\nviruses cause not only acute hepatitis but also various liver diseases, such as\nchronic hepatitis, liver cirrhosis and hepatocellular carcinoma due to persistent\ninfection.\nThe incidence of type A hapatitis markedly decreased after World War II\nin Japan. Whereas, it is still prevalent in South-Asia, Africa and Middle\nand South-America. Infection of hepatitis A virus is taken place by fecal-oral\nroute. However, there is no evidence for proliferation of this virus in the gut.\nHepatitis A virus is only found in the liver, especially in the hepatocytes in\nthe early stage and in the Kupffer cells in the late stage.\nThe spectrum of the clinical and pathological features caused by hepatitis B\nvirus is unusually broad, it also causes chronic hepatitis, liver cirrhosis, healthy\ncarrier and probably hepatocellular carciuoma due to persistent infection. Recently integration of hepatitis B virus genome into cancer cells of the hepatocellular carcinoma was confirmed by Southern blot hybridization method. Furthermore, several quite similar viruses with hepatitis B virus (hepadna viruses) were disclosed in different animal species, such as woodchuck, Pekin duck, grand squirrel etc. and those virues also cause chronic hepatitis and hepatocellular carcinoma in each animal species.","subitem_description_type":"Other"},{"subitem_description":"Hepatitis B virus and other hepadna viruses are found mainly in the blood.\nTherefore, transmission route of those viruses is quite different from hepatitis A\nvirus. Transmission is caused by parenteral routes, such as blood transfusion,\nintimate contact including sexual intercoures, vertcal transmission at birth. Difference of clinical coures and liver diseases caused by hepatitis B virus mainly depend on the age at which hepatitis B virus infects each persons. Infection in early life, such as newborn or infant usually does not cause acute hepatitis and cause chronic\npersistent infection. Some of those hepatitis B virus carriers later develop liver cirrhosis and hepatocellular carcinoma. Whereas, if immunologically competent adults are infected with hepatitis B virus, they develop acute hepatitis and later do not develop chronic hepatitis or liver cirrhosis.\nConcerning non-A, non-B hepatitis, causative viruses are not yet disclosed.\nChimpanzee have a susceptibility for those viruses. Hepatocyes of the infected chimpanzees show characteristic ultramicroscopical features. Recently we developed monoclonal antibody specific for non-A, non-B hepatitis by mean of EB virus transformation method of B lymphocytes of convalescent chimpanzee.","subitem_description_type":"Other"},{"subitem_description":"志方俊夫（日本大学医学部病理学講座・長崎大学熱帯医学研究所防疫部門）","subitem_description_type":"Other"}]},"item_7_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"シカタ, トシオ"}]}]},"item_7_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"SHIKATA, Toshio"}]}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_7_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15898"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15899"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15900"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10232/15901"}]}]},"item_7_relation_33":{"attribute_name":"関連（isVersionOf）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10232/15897","subitem_relation_type_select":"URI"}}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02892707","subitem_source_identifier_type":"ISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN10030752","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_7_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_7_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_7_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"Title page: http://hdl.handle.net/10232/15897, 序文: http://hdl.handle.net/10232/15898, 開会の辞: http://hdl.handle.net/10232/15899, 主旨説明: http://hdl.handle.net/10232/15900, 目次: http://hdl.handle.net/10232/15901"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"志方, 俊夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"AN10030752_v6_p25-47.pdf","filesize":[{"value":"8.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN10030752_v6_p25-47.pdf","url":"https://ir.kagoshima-u.ac.jp/record/5203/files/AN10030752_v6_p25-47.pdf"},"version_id":"e540251d-c92c-4fbe-9dcf-b7c47387b3e7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ウイルス性肝炎の疫学,臨床と病理","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ウイルス性肝炎の疫学,臨床と病理"}]},"item_type_id":"7","owner":"3","path":["94","5407"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-08"},"publish_date":"2015-06-08","publish_status":"0","recid":"5203","relation_version_is_last":true,"title":["ウイルス性肝炎の疫学,臨床と病理"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-12T06:36:29.548813+00:00"}