{"created":"2023-07-25T08:06:44.979198+00:00","id":5634,"links":{},"metadata":{"_buckets":{"deposit":"e144096f-2c0c-4ac4-95e7-37b4a3631c45"},"_deposit":{"created_by":18,"id":"5634","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"5634"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005634","sets":["57:80"]},"author_link":["28045"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(若手研究(B))研究成果報告書　課題番号：23792111　研究代表者：松尾美樹(鹿児島大学・大学院医歯学総合研究科・助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"黄色ブドウ球菌(Sa)の口腔内定着には、Saの持つ定着性因子、生体因子、口腔内細菌が産生する因子の少なくとも3因子が関与していることが明らかになった。Saの定着性因子としてsortase依存性菌体表層タンパクSasAを明らかにした。さらに、環境応答因子である二成分制御系因子、薬剤等の排出に関わるABCトランスポーターの関与も示唆された。生体因子としては高分子タンパクであるgp340がSasAと結合することで生体への定着を果たすことを明らかにした。また、先天性免疫機構である抗菌性ペプチドや、他の細菌が産生する抗菌性因子に対して抵抗性を持つことが、口腔内定着に重要な役割を果たすことが示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"It is revealed that at least 3 factors are related to colonization in oral cavity of Staphylococcus aureus (Sa): colonization factor in Sa, biogenic facors, and factors produced by oral bacteria. We showed that sortase-dependent cell surface protein SasA are the colonization factor in Sa. It is suggested that environmental response factor Two-component systems and ABC transporters, which are related to the efflux the drug, are important to colonization. It is observed that binding the high molecular protein gp340, as a biogenic factors, to SasA of Sa, made it possible to Sa-colonization in oral cavity. Furthermore, it is suggested that possess the resistance against antimicrobial peptides as congenital immunity and bacteriocins produced by other bacterium play an important role to colonization in oral cavity for Sa.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23792111"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松尾, 美樹","creatorNameLang":"ja"},{"creatorName":"MATSUO, Miki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28045","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020527048","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23792111.pdf","filesize":[{"value":"330.1 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23792111.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/5634/files/23792111.pdf"},"version_id":"4680ad33-6a09-41ad-bf5e-914fdbaa1a5b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"黄色ブドウ球菌の口腔内定着機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"黄色ブドウ球菌の口腔内定着機構の解明","subitem_title_language":"ja"},{"subitem_title":"Evaluation of oral cavity - colonization mechanism in Staphylococcus aureus","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"5634","relation_version_is_last":true,"title":["黄色ブドウ球菌の口腔内定着機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:04.650095+00:00"}