@article{oai:ir.kagoshima-u.ac.jp:00005647, author = {Fukushima, Kenjiro and 福島, 建次郎 and Okai, Yoshiko and 岡井, 佳子 and Matsuura, Shinobu and 松浦, 忍 and Tsujimoto, Hajime and 辻本, 元 and Endo, Yasuyuki and 遠藤, 泰之}, issue = {8}, journal = {The Journal of Veterinary Medical Science}, month = {}, note = {Molecular cloning of feline lung resistance-related protein (LRP) was performed to evaluate the relationship between its expression level and drug resistance against chemotherapeutics. The nucleotide sequence of the coding region of feline LRP cDNA was found to be 2670-bp long and to show 84.2–92.6% homology to its human, mouse, and rat counterparts. The expression level of feline LRP mRNA was relatively high in lung, jejunum, and colon. An adriamycin (ADM)-resistant feline lymphoma subline, FT-1/ADM, showed a high level of MDR1 mRNA expression compared with parental FT-1 cells. However, no relationship was observed between the drug-resistant phenotype and the LRP mRNA expression level. Although no direct contribution of LRP to the development of the drug-resistant phenotype was observed, further investigation is advisable.}, pages = {885--890}, title = {Molecular Cloning of Feline Lung Resistance-Related Protein (LRP) cDNA}, volume = {68}, year = {2006} }