@article{oai:ir.kagoshima-u.ac.jp:00005656,
 author = {Ishigami, Sumiya and 石神, 純也 and Arigami, Takaaki and 有上, 貴明 and Uenosono, Yoshikazu and 上之園, 芳一 and Okumura, Hiroki and 奥村, 浩 and Kurahara, Hiroshi and 藏原, 弘 and Uchikado, Yasuto and 内門, 泰斗 and Setoyama, Tetsuro and 瀬戸山, 徹郎 and Kita, Yoshiaki and 喜多, 芳昭 and Kijima, Yuko and 喜島, 祐子 and Nishizono, Yuka and 西園, 由香 and Nakajo, Akihiro and 中条, 哲浩 and Owaki, Tetsuhiro and 大脇, 哲洋 and Ueno, Shinichi and 上野, 真一 and Natsugoe, Shoji and 夏越, 祥次},
 journal = {Journal of Experimental and Clinical Cancer Research},
 month = {},
 note = {Background: Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified. 
Methods: Gastric cancer cell lines and 180 gastric cancer patients were enrolled. DLL4 expression in gastric cancer cells and stroma was identified and evaluated immunohistochemically. The association between DLL4 and clinicopathological factors was also assessed.
Results: DLL4 expression was identified in the cellular membrane and cytoplasm of gastric cancer cells by immunoblotting and immunohistochemical staining. DLL4 positivity in cancer cells and stroma was found in 88 (48%) and 41 (22%) of the 180 gastric cancer patients respectively. Both cancer and stromal DLL4 expression significantly correlated with more advanced tumor depth, nodal involvement, and lymphatic and venous invasion. A strongly positive association between cancerous and stromal DLL4 expression was identified (p < 0.01). Both cancerous and stromal DLL4 expression were prognostic markers in gastric cancer as determined by univariate analysis.
Conclusions: Cancerous and stromal DLL4 expression was found in 48% and 22% in gastric cancer, and significantly affected postoperative clinical outcomes. Cancerous and stromal DLL4 expression may be an effective target of anti-DLL4 treatment in gastric cancer.},
 title = {Clinical implications of DLL4 expression in gastric cancer},
 volume = {32},
 year = {2013},
 yomi = {イシガミ, スミヤ and アリガミ, タカアキ and ウエノソノ, ヨシカズ and オクムラ, ヒロシ and クラハラ, ヒロシ and ウチカド, ヤスト and セトヤマ, テツロウ and キタ, ヨシアキ and キジマ, ユウコ and ニシゾノ, ユカ and ナカジョウ, アキヒロ and オオワキ, テツヒロ and ウエノ, シンイチ and ナツゴエ, ショウジ}
}