{"created":"2023-07-25T08:06:45.938427+00:00","id":5656,"links":{},"metadata":{"_buckets":{"deposit":"6efa82c5-de5e-4ee9-b83e-2329acf994f3"},"_deposit":{"created_by":18,"id":"5656","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"5656"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005656","sets":["57:78"]},"author_link":["117011","117012","117013","117014","117015","117016","117017","117018","117019","117020","117021","117022","117023","117024"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"46","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Journal of Experimental and Clinical Cancer Research","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-07-30","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor neovascular development and angiogenesis during tumor growth. The clinical significance of DLL4 expression in gastric cancer has not been clarified. \nMethods: Gastric cancer cell lines and 180 gastric cancer patients were enrolled. DLL4 expression in gastric cancer cells and stroma was identified and evaluated immunohistochemically. The association between DLL4 and clinicopathological factors was also assessed.\nResults: DLL4 expression was identified in the cellular membrane and cytoplasm of gastric cancer cells by immunoblotting and immunohistochemical staining. DLL4 positivity in cancer cells and stroma was found in 88 (48%) and 41 (22%) of the 180 gastric cancer patients respectively. Both cancer and stromal DLL4 expression significantly correlated with more advanced tumor depth, nodal involvement, and lymphatic and venous invasion. A strongly positive association between cancerous and stromal DLL4 expression was identified (p < 0.01). Both cancerous and stromal DLL4 expression were prognostic markers in gastric cancer as determined by univariate analysis.\nConclusions: Cancerous and stromal DLL4 expression was found in 48% and 22% in gastric cancer, and significantly affected postoperative clinical outcomes. Cancerous and stromal DLL4 expression may be an effective target of anti-DLL4 treatment in gastric cancer.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1756-9966-32-46","subitem_relation_type_select":"DOI"}}]},"item_6_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2013 Ishigami et al; licensee BioMed Central Ltd.","subitem_rights_language":"en"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17569966","subitem_source_identifier_type":"EISSN"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishigami, Sumiya","creatorNameLang":"en"},{"creatorName":"イシガミ, スミヤ","creatorNameLang":"ja-Kana"},{"creatorName":"石神, 純也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arigami, Takaaki","creatorNameLang":"en"},{"creatorName":"アリガミ, タカアキ","creatorNameLang":"ja-Kana"},{"creatorName":"有上, 貴明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uenosono, Yoshikazu","creatorNameLang":"en"},{"creatorName":"ウエノソノ, ヨシカズ","creatorNameLang":"ja-Kana"},{"creatorName":"上之園, 芳一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, Hiroki","creatorNameLang":"en"},{"creatorName":"オクムラ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"奥村, 浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurahara, Hiroshi","creatorNameLang":"en"},{"creatorName":"クラハラ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"藏原, 弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchikado, Yasuto","creatorNameLang":"en"},{"creatorName":"ウチカド, ヤスト","creatorNameLang":"ja-Kana"},{"creatorName":"内門, 泰斗","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Setoyama, Tetsuro","creatorNameLang":"en"},{"creatorName":"セトヤマ, テツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"瀬戸山, 徹郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kita, Yoshiaki","creatorNameLang":"en"},{"creatorName":"キタ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"喜多, 芳昭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kijima, Yuko","creatorNameLang":"en"},{"creatorName":"キジマ, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"喜島, 祐子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishizono, Yuka","creatorNameLang":"en"},{"creatorName":"ニシゾノ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"西園, 由香","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajo, Akihiro","creatorNameLang":"en"},{"creatorName":"ナカジョウ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"中条, 哲浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Owaki, Tetsuhiro","creatorNameLang":"en"},{"creatorName":"オオワキ, テツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"大脇, 哲洋","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Shinichi","creatorNameLang":"en"},{"creatorName":"ウエノ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"上野, 真一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Natsugoe, Shoji","creatorNameLang":"en"},{"creatorName":"ナツゴエ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"夏越, 祥次","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117024","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"Clinical implications of DLL4 expression in gastric cancer.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Clinical implications of DLL4 expression in gastric cancer.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/5656/files/Clinical implications of DLL4 expression in gastric cancer.pdf"},"version_id":"3cdb1740-cf99-4a0b-be93-80db6cf88bed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Delta-like ligand 4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphatic invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymph node metastases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peritumoral stroma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical implications of DLL4 expression in gastric cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical implications of DLL4 expression in gastric cancer","subitem_title_language":"en"}]},"item_type_id":"6","owner":"18","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-04-04"},"publish_date":"2014-04-04","publish_status":"0","recid":"5656","relation_version_is_last":true,"title":["Clinical implications of DLL4 expression in gastric cancer"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-02-07T06:19:25.688895+00:00"}