@article{oai:ir.kagoshima-u.ac.jp:00005657,
 author = {Ishigami, Sumiya and 石神, 純也 and Ueno, Shinichi and 上野, 真一 and Nishizono, Yuka and 西園, 由香 and Matsumoto, Masataka and 松本, 正隆 and Kurahara, Hiroshi and 蔵原, 弘 and Arigami, Takaaki and 有上, 貴明 and Uchikado, Yasuto and 内門, 泰斗 and Setoyama, Tetsuro and 瀬戸山徹郎 and Arima, Hideo and 有馬, 豪男 and Kita, Yoshiaki and 喜多, 芳昭 and Kijima, Yuko and 喜島, 祐子 and Kitazono, Masaki and 北薗, 正樹 and Natsugoe, Shoji and 夏越, 祥次},
 journal = {BMC Cancer},
 month = {},
 note = {Background: Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HAmediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear.
Methods: We examined the CD168 expression of 196 consecutive gastric cancer patients by immunohistochemistry. According to CD168 positivity, the 196 gastric cancer patients were divided into two groups (57 CD168-positive and 139 CD168-negative patients). The correlation between CD168 expression and clinicopathological factors (age, sex, histology, tumor depth, lymph node status, and vessel invasion) was evaluated according to the Japanese Classification of Gastric Carcinoma.
Results: Cancerous CD168 expression was detectable in 57 of the 196 tumors (29%). CD168 positivity was significantly correlated with the depth of invasion, nodal involvement, and vessel invasion (p < 0.01). Survival analysis of the 196 gastric cancer patients showed that the CD168-positive group had a significantly higher mortality than the CD168-negative group (p < 0.01). In terms of a correlation with CD168 positivity at separate clinical stages, a significance difference was only found in stages II and III. Multivariate analysis revealed that CD168 expression was a significant independent prognostic marker (p = 0.013) after depth of invasion (p < 0.005) and nodal involvement (p < 0.01).
Conclusion: Our results suggest that cancerous CD168 positivity is strongly  related to the invasion and metastasis of gastric cancer tumors. These results suggest that cancerous CD168 expression can be used as a prognostic marker of gastric cancer owing to its interactions with stromal hyaluronic acid.},
 title = {Prognostic impact of CD168 expression in gastric cancer},
 volume = {11},
 year = {2011},
 yomi = {イシガミ, スミヤ and ウエノ, シンイチ and ニシゾノ, ユカ and マツモト, マサタカ and クラハラ, ヒロシ and アリガミ, タカアキ and ウチカド, ヤスト and セトヤマ, テツロウ and アリマ, ヒデオ and キタ, ヨシアキ and キジマ, ユウコ and キタゾノ, マサキ and ナツゴエ, ショウジ}
}