{"created":"2023-07-25T08:06:45.982160+00:00","id":5657,"links":{},"metadata":{"_buckets":{"deposit":"ccdc303d-1de9-4bca-89f2-af8487c68974"},"_deposit":{"created_by":18,"id":"5657","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"5657"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00005657","sets":["57:78"]},"author_link":["117053","117054","117055","117056","117057","117058","117059","117060","117061","117062","117063","117064","117065"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"106","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"BMC Cancer","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-03-24","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HAmediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear.\nMethods: We examined the CD168 expression of 196 consecutive gastric cancer patients by immunohistochemistry. According to CD168 positivity, the 196 gastric cancer patients were divided into two groups (57 CD168-positive and 139 CD168-negative patients). The correlation between CD168 expression and clinicopathological factors (age, sex, histology, tumor depth, lymph node status, and vessel invasion) was evaluated according to the Japanese Classification of Gastric Carcinoma.\nResults: Cancerous CD168 expression was detectable in 57 of the 196 tumors (29%). CD168 positivity was significantly correlated with the depth of invasion, nodal involvement, and vessel invasion (p < 0.01). Survival analysis of the 196 gastric cancer patients showed that the CD168-positive group had a significantly higher mortality than the CD168-negative group (p < 0.01). In terms of a correlation with CD168 positivity at separate clinical stages, a significance difference was only found in stages II and III. Multivariate analysis revealed that CD168 expression was a significant independent prognostic marker (p = 0.013) after depth of invasion (p < 0.005) and nodal involvement (p < 0.01).\nConclusion: Our results suggest that cancerous CD168 positivity is strongly  related to the invasion and metastasis of gastric cancer tumors. These results suggest that cancerous CD168 expression can be used as a prognostic marker of gastric cancer owing to its interactions with stromal hyaluronic acid.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1471-2407-11-106","subitem_relation_type_select":"DOI"}}]},"item_6_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2011 Ishigami et al; licensee BioMed Central Ltd.","subitem_rights_language":"en"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14712407","subitem_source_identifier_type":"EISSN"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishigami, Sumiya","creatorNameLang":"en"},{"creatorName":"イシガミ, スミヤ","creatorNameLang":"ja-Kana"},{"creatorName":"石神, 純也","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueno, Shinichi","creatorNameLang":"en"},{"creatorName":"ウエノ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"上野, 真一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishizono, Yuka","creatorNameLang":"en"},{"creatorName":"ニシゾノ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"西園, 由香","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Masataka","creatorNameLang":"en"},{"creatorName":"マツモト, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"松本, 正隆","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurahara, Hiroshi","creatorNameLang":"en"},{"creatorName":"クラハラ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"蔵原, 弘","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arigami, Takaaki","creatorNameLang":"en"},{"creatorName":"アリガミ, タカアキ","creatorNameLang":"ja-Kana"},{"creatorName":"有上, 貴明","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchikado, Yasuto","creatorNameLang":"en"},{"creatorName":"ウチカド, ヤスト","creatorNameLang":"ja-Kana"},{"creatorName":"内門, 泰斗","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Setoyama, Tetsuro","creatorNameLang":"en"},{"creatorName":"セトヤマ, テツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"瀬戸山徹郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arima, Hideo","creatorNameLang":"en"},{"creatorName":"アリマ, ヒデオ","creatorNameLang":"ja-Kana"},{"creatorName":"有馬, 豪男","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kita, Yoshiaki","creatorNameLang":"en"},{"creatorName":"キタ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"喜多, 芳昭","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kijima, Yuko","creatorNameLang":"en"},{"creatorName":"キジマ, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"喜島, 祐子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitazono, Masaki","creatorNameLang":"en"},{"creatorName":"キタゾノ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"北薗, 正樹","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Natsugoe, Shoji","creatorNameLang":"en"},{"creatorName":"ナツゴエ, ショウジ","creatorNameLang":"ja-Kana"},{"creatorName":"夏越, 祥次","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"Prognostic impact of CD168 expression in gastric cancer.pdf","filesize":[{"value":"599.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Prognostic impact of CD168 expression in gastric cancer.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/5657/files/Prognostic impact of CD168 expression in gastric cancer.pdf"},"version_id":"01821a08-2f22-4e86-9ca8-cf27aa2ca768"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prognostic impact of CD168 expression in gastric cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic impact of CD168 expression in gastric cancer","subitem_title_language":"en"}]},"item_type_id":"6","owner":"18","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-01-16"},"publish_date":"2014-01-16","publish_status":"0","recid":"5657","relation_version_is_last":true,"title":["Prognostic impact of CD168 expression in gastric cancer"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-02-07T06:19:30.360739+00:00"}