{"created":"2023-07-25T08:07:00.878266+00:00","id":6000,"links":{},"metadata":{"_buckets":{"deposit":"8a8efb30-738a-4abc-8cb9-46eb1f2654df"},"_deposit":{"created_by":3,"id":"6000","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6000"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00006000","sets":[]},"author_link":["117935","117936","6518"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Extracellular histones as a myocardial depressant factor"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"シンキン ショウガイ ブンシ トシテノ サイボウガイ ヒストン ノ キソ ケンキュウ ト リンショウ テンカイ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-13"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2013-2013年度科学研究費助成事業（挑戦的萌芽研究）研究成果報告書　課題番号：25670763　研究代表者：伊藤隆史（鹿児島大学・医歯（薬）学総合研究科・特任講師）","subitem_description_type":"Other"},{"subitem_description":"敗血症患者の血中ヒストン濃度を測定したところ、健常人と比べて有意に高かった。マウスの血中にヒストンを投与して、重症敗血症患者と同程度まで血中ヒストン濃度を上昇させると、心電図検査、心エコー検査、血液検査にて、心筋傷害の所見を認めた。敗血症に伴う血液凝固異常の治療薬として臨床応用されている遺伝子組換え型トロンボモジュリン製剤をマウスに投与すると、ヒストンによる心筋傷害を軽減し、生存率を改善することができた。以上のことから、敗血症の際に血中濃度が上昇するヒストンは、心筋傷害因子として作用する可能性が示唆され、遺伝子組換え型トロンボムジェリン製剤によってそれを軽減しうる可能性が示唆された。","subitem_description_type":"Other"},{"subitem_description":"This study examined infants' ability to perceive artificially produced three-dimensional object. In order to control shapes of three-dimensional objects, we created three-dimensional face and non-face objects (shoes) that contained no texture. First, behavioral study investigated infants' ability to learn the faces and non-face objects. Results were compared between categories and those showed the infants' ability to learn faces differs from their ability to learn non-face objects. Next, behavioral and brain activity measurement studies investigated effect of eye gaze direction of the faces. Results showed that infants could learn three-dimensional face by 8 months of age only in direct gaze. This suggested that gaze direction may affect three-dimensional face learning in infants.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"イトウ, タカシ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ITO, Takashi"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"25670763"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 隆史"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"25670763_伊藤隆史.pdf","filesize":[{"value":"321.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25670763_伊藤隆史.pdf","url":"https://ir.kagoshima-u.ac.jp/record/6000/files/25670763_伊藤隆史.pdf"},"version_id":"ee5f68af-6578-4aab-b8a8-8659690f1aba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫学","subitem_subject_scheme":"Other"},{"subitem_subject":"病理学","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒストン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心筋障害分子としての細胞外ヒストンの基礎研究と臨床展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心筋障害分子としての細胞外ヒストンの基礎研究と臨床展開"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-20"},"publish_date":"2015-05-20","publish_status":"0","recid":"6000","relation_version_is_last":true,"title":["心筋障害分子としての細胞外ヒストンの基礎研究と臨床展開"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:53.752977+00:00"}