{"created":"2023-07-25T08:07:01.104495+00:00","id":6005,"links":{},"metadata":{"_buckets":{"deposit":"e19705d8-d818-4463-a1bc-19efa86f8873"},"_deposit":{"created_by":3,"id":"6005","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6005"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00006005","sets":[]},"author_link":["117940","27928","117939"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Invasive Streptococcus mutans induces inflammatory cytokine production of human aortic endothelial cells via regulation of TLR2 and NOD2"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ミュータンス レンサ キュウキン ニヨル シンキ ドウミャク コウカ ハッショウ キジョ ノ カイメイ : キン ノ サイボウナイ シンニュウ ト ニンシキ オウトウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-05-28"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23593094　研究代表者：長田恵美（鹿児島大学・医歯（薬）学総合研究科・助教）","subitem_description_type":"Other"},{"subitem_description":"我々は動脈硬化の新たなリスクファクター候補として、う蝕原因細菌であるミュータンスレンサ球菌に着目し、侵入した菌に対するヒト動脈内皮細胞の認識応答機序を検討した。調べた異なる血清型のミュータンスレンサ球菌は、全てヒト動脈内皮細胞への侵入能力を有していた。菌が侵入していない内皮細胞と較べて、菌が侵入したヒト動脈内皮細胞における炎症サイトカインの産生、およびパターン認識受容体であるTLR2およびNOD2の発現は、増加していた。TLR2およびNOD2の発現を抑制すると、ヒト動脈内皮細胞における炎症サイトカインの産生は減少した。以上の結果より、ミュータンスレンサ球菌の動脈硬化発症への関与が示唆された。","subitem_description_type":"Other"},{"subitem_description":"We focused on Streptococcus mutans as one of the new candidates of risk factors to cause atherosclerosis, and examined the recognition mechanism of human aortic endothelial cells (HAECs) for invasive Streptococcus mutans. All six strains tested, consisting of three different serotypes of S. mutans, were capable of invading HAECs. HAECs invaded by S. mutans produced larger amounts of cytokines, and the messenger RNA expression of TLR2 and NOD2 increased markedly compared with that by non-invaded HAECs. The production of cytokines by invaded HAECs decreased when the expression of TLR2 and/or NOD2 mRNA of HAECs was inhibited. These results suggest that invasive S. mutans may induce inflammatory reaction of HAECs through the recognition process via TLR2 and NOD2.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ナガタ, エミ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NAGATA, Emi"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23593094"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長田, 恵美"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23593094_長田恵美.pdf","filesize":[{"value":"208.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23593094_長田恵美.pdf","url":"https://ir.kagoshima-u.ac.jp/record/6005/files/23593094_長田恵美.pdf"},"version_id":"6084c3d7-45ad-4ea5-8cae-dc5cdd29addb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ミュータンスレンサ球菌","subitem_subject_scheme":"Other"},{"subitem_subject":"内皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR2","subitem_subject_scheme":"Other"},{"subitem_subject":"NOD2","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔細菌","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ミュータンスレンサ球菌による新規動脈硬化発症機序の解明 : 菌の細胞内侵入と認識応答","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミュータンスレンサ球菌による新規動脈硬化発症機序の解明 : 菌の細胞内侵入と認識応答"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"6005","relation_version_is_last":true,"title":["ミュータンスレンサ球菌による新規動脈硬化発症機序の解明 : 菌の細胞内侵入と認識応答"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:54.240954+00:00"}