{"created":"2023-07-25T08:07:01.193899+00:00","id":6007,"links":{},"metadata":{"_buckets":{"deposit":"88355fb2-e4ca-42d4-b36f-cc7d9b8b6e4a"},"_deposit":{"created_by":3,"id":"6007","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"6007"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00006007","sets":[]},"author_link":["74379","74378","29268"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Significance as a therapeutic target and elucidation of EMT in a low oxygen environment of oral squamous cell carcinoma"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"コウクウ ヘンペイ ジョウヒ ガン ノ テイサンソ カンキョウ ニオケル EMT ノ カイメイ ト チリョウ ヒョウテキ トシテノ イギ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-24"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23592968　研究代表者：石田喬之（鹿児島大学・医学部・歯学部附属病院・助教）","subitem_description_type":"Other"},{"subitem_description":"口腔癌細胞株を低酸素環境と通常環境で培養し、運動能と浸潤能、E-cadherinの発現を比較した。結果、低酸素環境での亢進を認め、Notch阻害薬を添加することでそれらは抑制された。またNotch阻害薬のまたリアルタイムPCRにてNotch関連因子の発現を調べたところ、低酸素環境でNotch関連因子の発現の亢進を認めた。以上より低酸素環境はNotch経路を介して口腔癌細胞株にEMTを誘導している可能性が示唆され、口腔癌の転移抑制の治療標的になりうることが示唆された。","subitem_description_type":"Other"},{"subitem_description":"We compared invasion and motility and expression of E-cadherin in oral cancer cell linescultured in a normal environment and low oxygen environment. They were increased in a low oxygen environment, but suppressed by the addition of Notch inhibitors. We examined the expression of Notch-related factors in the real time PCR, showed an enhanced expression of Notch signaling in a low-oxygen environment. These results suggested possibility that induce EMT in oral cancer cell lines via the Notch pathway by low oxygen environments, and might suggest Notch passway to be a therapeutic target for inhibiting metastasis of oral cancer.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"イシダ, タカユキ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ISHIDA, Takayuki"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23592968"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石田, 喬之"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23592968_ishida_takayuki.pdf","filesize":[{"value":"87.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23592968_石田喬之.pdf","url":"https://ir.kagoshima-u.ac.jp/record/6007/files/23592968_ishida_takayuki.pdf"},"version_id":"da800a15-9180-4954-b4b2-62874c87c87c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔癌","subitem_subject_scheme":"Other"},{"subitem_subject":"低酸素","subitem_subject_scheme":"Other"},{"subitem_subject":"EMT","subitem_subject_scheme":"Other"},{"subitem_subject":"Notch","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔扁平上皮癌の低酸素環境におけるEMTの解明と治療標的としての意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔扁平上皮癌の低酸素環境におけるEMTの解明と治療標的としての意義"}]},"item_type_id":"8","owner":"3","path":["83"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"6007","relation_version_is_last":true,"title":["口腔扁平上皮癌の低酸素環境におけるEMTの解明と治療標的としての意義"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-01-29T08:29:08.866116+00:00"}