{"created":"2023-07-25T08:07:01.282816+00:00","id":6009,"links":{},"metadata":{"_buckets":{"deposit":"e6b6a279-edd5-4d2d-9c21-ece92327a444"},"_deposit":{"created_by":18,"id":"6009","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"6009"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00006009","sets":["57:80"]},"author_link":["29274"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-05-29","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23590680　研究代表者：飯島幹雄（鹿児島大学・医歯（薬）学総合研究科・助教）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"シトリンの欠損は、シトリン欠損による新生児肝内胆汁うっ滞と成人発症II型シトルリン血症の原因となる。シトリン欠損症の確定診断は、遺伝子診断が主として用いられるが、既存の変異が両アレルに検出できない症例が存在する。ウェスタンブロット法もシトリン欠損症に用いられているが、手間が掛かるためその利用は非常にまれである。イムノクロマト法は、近年開発された、手軽で迅速な検出手段である。本研究の目的は、確定診断を補完する、イムノクロマト法による口腔粘膜細胞を用いたシトリンタンパク質の検出である。本研究期間で、シトリンタンパク質に対するイムノクロマト測定系の確立には至らなかった。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Citrin deficiency causes neonatal  intrahepatic cholestasis caused by citrin deficiency, and adult-onset type II citrullinemia. Diagonosis of  citrin deficiency is mainly performed by genetic analysis, although the known mutations are not detected in some cases. Western blot analysis is also performed for citrin deficiency. The use of Western blot analysis is very few because it is time-consuming. I \n mmunochromatography is recently developed detection method, which is easy and quick. The aim of this project is to examine citrin protein in oral mucosae by using immunochromatography as an alternative diagnostic method. In this project, the development of  immunochromatography for a citrin protein was not completed.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23590680"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"飯島, 幹雄","creatorNameLang":"ja"},{"creatorName":"IIJIMA, Mikio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29274","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000305111","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23590680_飯島幹雄.pdf","filesize":[{"value":"375.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23590680_飯島幹雄.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/6009/files/23590680_飯島幹雄.pdf"},"version_id":"91ec0f3e-3a85-4015-b5e3-8dcf8b2b9306"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"イムノクロマト法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ミトコンドリア　","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アスパラギン酸・グルタミン酸輸送体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"イムノクロマト法によるシトリン欠損症迅速簡便診断法の開発と臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"イムノクロマト法によるシトリン欠損症迅速簡便診断法の開発と臨床応用","subitem_title_language":"ja"},{"subitem_title":"Development and clinical application of the immunochromatography for a citrin protein","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"6009","relation_version_is_last":true,"title":["イムノクロマト法によるシトリン欠損症迅速簡便診断法の開発と臨床応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:03.860664+00:00"}