{"created":"2023-07-25T08:07:01.771795+00:00","id":6020,"links":{},"metadata":{"_buckets":{"deposit":"a17380a1-bdfd-4162-bfea-651cfbfc9408"},"_deposit":{"created_by":18,"id":"6020","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"6020"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00006020","sets":["82:83"]},"author_link":["4647"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-08-13","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23592135　研究代表者：平野宏文（鹿児島大学医学部・歯学部附属病院・講師）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"予後不良疾患である膠芽腫は周囲組織へ浸潤する時MMPが関与しており、分泌性糖タンパク質であるWntは、受容体Fzd, Ror2, Rykと結合する。先行論文で膠芽腫ではWnt-5aが高発現し、MMP-2を上昇させることを報告した。今回はMMP-2を介した細胞浸潤は受容体Rykを介していることを発見した。また悪性度とFzd2, Rykの発現が相関することが分かった（J Biochem 2014）。膠芽腫ではFzd2とFzd6の高発現が予後不良因子であることも報告した（Brain Tumor Pathol 2013）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Glioblastoma, one of the most malignant brain tumors, invade surrounding brain by expression of MMPs. Wnts, secretory proteins bind to their receptors, Fzd, Ror2, and Ryk. We previously reported that Wnt-5a was highly expressed and it up-regulated MMP-2 in glioblastoma. In this work, we revealed that tumor cell invasion by MMP-2 was achieved via receptor Ryk, and the degree of histological malignancy correlated with expression of Fzd2 and Ryk (J Biochem 2014,  doi:  10.1093/jb/mvu 015). In another analysis, we reported that high expression of Fzd2 and Fzd6 was poor prognostic factor in glioblastoma patients (Brain Tumor Pathol 2013, 10.1007/s10014-013-0153-1).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23592135"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平野, 宏文","creatorNameLang":"ja"},{"creatorName":"HIRANO, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23592135_hirano_hirofumi_revised.pdf","filesize":[{"value":"550.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23592135_hirano_hirofumi_revised.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/6020/files/23592135_hirano_hirofumi_revised.pdf"},"version_id":"81fc50cd-47f2-4f74-9fa8-1b9724460dae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"glioblastoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt-5a","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MMP-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fzd2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fdz6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ryk","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ror2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Wnt/Frizzled系主要メッセージ経路探索による新しい抗グリオーマ戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Wnt/Frizzled系主要メッセージ経路探索による新しい抗グリオーマ戦略","subitem_title_language":"ja"},{"subitem_title":"New anti-glioma treatment strategy by clarification of dominat Wnt/Frezzled massage","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-26"},"publish_date":"2015-05-26","publish_status":"0","recid":"6020","relation_version_is_last":true,"title":["Wnt/Frizzled系主要メッセージ経路探索による新しい抗グリオーマ戦略"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:30.042254+00:00"}