{"created":"2023-07-25T08:07:11.319662+00:00","id":6211,"links":{},"metadata":{"_buckets":{"deposit":"f5a7cf34-f4da-4af4-9219-195e44503c32"},"_deposit":{"created_by":18,"id":"6211","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"6211"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00006211","sets":["228:274:4797","64:65"]},"author_link":[],"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-03-25","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"23","bibliographicPageStart":"9","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"鹿児島大学歯学部紀要","bibliographic_titleLang":"ja"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1998-03-25","subitem_date_issued_type":"Issued"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"The unprecedented speed with which the etiologic agent of AIDS, human immunodeficiency virus (HIV) , was isolated and characterized, and then effective drugs were discovered remarkably. Discovery of some anti-HIV compounds suggested that the antiviral chemotherapy of AIDS was fesible, and opened the search for more potent and more selective anti-HIV agents. In the past two years, HIV-infected patients have been treated with combinations of drugs which inhibit enzymes present in HIV but not in human. Most have thereupon become able to forestall or even overcome opportunistic infections, and have exhibited decresed quantities of viral load and increased numbers of CD4 Iymphocytes. In addition, HIV coreceptors, CXCR4 and CCR5,were identified and their important roles for virus entry would be disclosuring. This review will focus on the latest basic research of AIDS and anti-HIV drug development.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03897834","subitem_source_identifier_type":"PISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0035442X","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_7_subject_20":{"attribute_name":"NIIsubject","attribute_value_mlt":[{"subitem_subject":"歯学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中島, 秀喜","creatorNameLang":"ja"},{"creatorName":"NAKASHIMA, Hideki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"KJ00000165816.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000165816.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/6211/files/KJ00000165816.pdf"},"version_id":"ade9e5dd-db52-465c-8ce6-b1849321941f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"AIDS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV infection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-HIV drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CXCR4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CCR5","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"エイズおよび抗HIV薬開発研究について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エイズおよび抗HIV薬開発研究について","subitem_title_language":"ja"},{"subitem_title":"AIDS and the Development of Anti-human Immunodeficiency Virus(HIV)Drugs","subitem_title_language":"en"}]},"item_type_id":"7","owner":"18","path":["65","4797"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-04-06"},"publish_date":"2015-04-06","publish_status":"0","recid":"6211","relation_version_is_last":true,"title":["エイズおよび抗HIV薬開発研究について"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-26T07:10:32.113938+00:00"}