@article{oai:ir.kagoshima-u.ac.jp:00006796,
 author = {Hasui, Kazuhisa and Shirahama, Hiroshi and Sueyoshi, Kazunobu and Sato, Eiichi and Imakuma, Mitsuru},
 journal = {Dendritic cells},
 month = {Jan},
 note = {ln a HTLV-1 carrier Japanese man gastric T cell-rich B cell lymphoma occurred at 67 years of age and nodal T cell malignant lymphoma appeared at 72 years of age. The gastric T-cell rich B-cell Iymphoma formed an ulcerated tumor in the posterior wall of the body, involving up to the serosa and regional lymph nodes. A few lymphoma cells had cytoplasmic monoclonal κ and λ type immunoglobulin. Signals of HTLV-l pX Tax DNA sequence and stains of three antibodies against HTLV-1-encoded proteins  (gp46env, p40tax and p19gag) in some lymphoma cells suggested that this gastric lymphoma was a HTLV-1-related case. Six years later, large cell type T-cell malignant 
lymphoma occurred in left inguinal lymph node. Many S100+ dendritic cells and ysozyme+ cells were intermingling among the lymphoma cells. Some epithelioid cells among the lymphoma cells showed weak stains of the three antibodies against HTLV-l-encoded proteins. The PCR analysis showed oligoclonal rearrangement bands of TCRβ gene in the agar-gel electrophoresis. After three months' follow-up without chemotherapy, recurrent swelling of left inguinal lymph node and splenomegaly appeared. After chemotherapy the biopsied left inguinal lymph node showed necrosis and residual T cell malignant lymphoma. The uncommon features such as many T cells in the gastric lymphoma and many S100+ cells, many lysozyme+ cells and oligoclonal rearrangement of TCRβ gene in the nodal T-cell lymphoma might be induced by HTLV-1 infection. The patient has survived without any complaints. The HTLV-l-related lymphoid malignancies other than adult T-cell leukemia/lymphoma would be not-aggressive and might be the diseases in the microenvironment under the immunocompromised state in HTLV-1 carrier.},
 pages = {14--21},
 title = {Metachronous occurrence of gastric T-cell rich B-cell lymphoma and nodal T-cell lymphoma in a HTLV-1 carrier},
 volume = {6},
 year = {1996}
}