{"created":"2023-07-25T08:02:52.763499+00:00","id":701,"links":{},"metadata":{"_buckets":{"deposit":"cf6dcb1b-2e82-4c92-978a-b2c83cb19592"},"_deposit":{"created_by":18,"id":"701","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"701"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00000701","sets":["57:80"]},"author_link":["4652"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(B))研究成果報告書 課題番号：20390199　研究代表者：乾明夫 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"難治性神経代謝疾患として、カルニチン輸送体（OCTN2）欠損症、シトリン欠損症、有棘赤血球舞踏病等の先天性代謝疾患や、癌性悪液質、神経性食欲不振症、うつ病等の多因子性疾患を取り上げ、トランスレーショナルな立場から研究を行った。JVS マウスやシトリン欠損症、癌性悪液質モデル動物等を作製し、病態解析を行い、アセチルカルニチン、ピルビン酸、グレリンアゴニスト、六君子湯などの新たな治療法を創出し、臨床応用を試みた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"The translational research was conducted on intractable nuero-metablic disorders such as congenital diseases including carnitine carrier deficiency, citrin deficiency and chorea acantosis, and maltifactorial diseases including cancer cachexia, eating disorders and mood disorders. JVS mouse and animal models of cancer cachexia and citrin deficiency were created and used on pathological analysis. New treatment methods, such as acetylcarnitine, pyruvic acid, ghrelin agonist and Rikkunshito, were created or applied clinically from this research work.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20390199"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"乾, 明夫","creatorNameLang":"ja"},{"creatorName":"INUI, Akio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4652","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080168418","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"20390199seika.pdf","filesize":[{"value":"247.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"20390199seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/701/files/20390199seika.pdf"},"version_id":"d1bdcd05-e9a4-4780-b477-c2d299984e43"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"医療・福祉","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"神経医学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスレーショナルリサーチ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"臨床","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"難治性神経代謝疾患に対するトランスレーショナルリサーチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"難治性神経代謝疾患に対するトランスレーショナルリサーチ","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"701","relation_version_is_last":true,"title":["難治性神経代謝疾患に対するトランスレーショナルリサーチ"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:07.068021+00:00"}