{"created":"2023-07-25T08:08:19.436233+00:00","id":7672,"links":{},"metadata":{"_buckets":{"deposit":"709f5d63-b2a8-4d33-af86-bbe76b51030c"},"_deposit":{"created_by":18,"id":"7672","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"7672"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00007672","sets":["82:83"]},"author_link":["14877"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：21792090　研究代表者：山本芳丈 (鹿児島大学医学部・歯学部附属病院助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"歯科矯正治療に不可欠である骨リモデリングや再生に関わる骨芽細胞の分化制御機構に関与すると考えられるMsx2については未だ不明な点が多い。そこで本研究ではマウスES細胞を用いて骨芽細胞への分化や骨形成に対する役割について検討した。Msx2を導入したES細胞とフィーダー細胞を共存培養し、その分化能を検討するためにALP染色および分化関連遺伝子のmRNA発現、さらに石灰化能について調べた。結果より骨芽細胞の分化に対して重要な役割を担うものと考えられた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"To date, there have been no clear reports that Msx2 take part in the mechanism of osteoblast differentiation, which is responsible for the bone remodeling and regeneration in orthodontic treatments. The purpose of the present study, therefore, was to investigate the roles of Msx2 in osteoblast differentiation and bone formation with mouse Embryonic Stem cells. ES cells which transfected with Msx2 were cocultured with feeder cells, and alkaline phosphatase activity and mRNA levels of osteoblastic phenotype were determined for cell differentiation. The value of bone nodules was also determined for mineralization. As a result, it was suggested that Msx2 play a key role in controlling osteoblast differentiation.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21792090"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 芳丈","creatorNameLang":"ja"},{"creatorName":"YAMAMOTO, Yoshitake","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14877","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050380465","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21792090seika.pdf","filesize":[{"value":"185.0 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21792090seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/7672/files/21792090seika.pdf"},"version_id":"362a0912-2117-4d1a-af53-e42b3ab764d7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨芽細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨リモデリングに関わる骨芽細胞の増殖・分化・機能活性におけるMsx2の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨リモデリングに関わる骨芽細胞の増殖・分化・機能活性におけるMsx2の役割","subitem_title_language":"ja"},{"subitem_title":"Roles of Msx2 in osteoblast proliferation, differentiation and activation for bone remodeling","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"7672","relation_version_is_last":true,"title":["骨リモデリングに関わる骨芽細胞の増殖・分化・機能活性におけるMsx2の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:14.774649+00:00"}