{"created":"2023-07-25T08:08:19.651526+00:00","id":7677,"links":{},"metadata":{"_buckets":{"deposit":"0fd10aed-2ce9-425f-bc97-ebe9b8a9b8c2"},"_deposit":{"created_by":3,"id":"7677","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7677"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00007677","sets":[]},"author_link":["117952","117951","27953"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The study of preterm low birth weight associated with periodontal disease"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"シシュウビョウ ガ ソウザン・テイタイジュウジ シュッサン ニ アタエル エイキョウ ニ カンスル ホウカツテキ ケンキュウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-31"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：21792126　研究代表者：長谷川梢 (鹿児島大学医歯学総合研究科助教)","subitem_description_type":"Other"},{"subitem_description":"23名のハイリスク妊婦のうち、２名の切迫早産妊婦、２名の多胎妊娠妊婦、２名の前置胎盤妊婦の絨毛膜組織からPorphyromonas gingivalis (P.gingivalis)が検出された。絨毛膜由来細胞をP.gingivalis LPSで刺激すると、培養上清中のIL-6とIL-8レベルとTLR-2の遺伝子発現は有意に上昇したが、TLR-2遺伝子の発現を抑制することにより減少した。これらのことから、子宮内組織に定着したP.gingivalisがTLR-2を介して、早産に関連する炎症性物質を誘導することにより、早産を引き起こす可能性が示唆された。","subitem_description_type":"Other"},{"subitem_description":"P.gingivalis DNA was detected in chorionic tissues from six out of 23 high-risk pregnant women. Stimulation of chorion-derived cells with P.gingivalis LPS significantly increased TLR-2 mRNA expression and induced IL-6 and IL-8 production in chorion-derived cells. P.gingivalis LPS-induced IL-6 and IL-8 production was reduced in TLR-2 gene-silenced chorion-derived cells.It is very likely that P.gingivalis staying in intrauterine tissues breaks the maintenance of a proper uterine-fetus relationship via TLR-2 by generating pro-inflammatory cytokines, which may cause premature labor.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ハセガワ, コズエ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"HASEGAWA, Kozue"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21792126"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 梢"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21792126seika.pdf","filesize":[{"value":"307.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21792126seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/7677/files/21792126seika.pdf"},"version_id":"8f19957c-4110-4023-8dc5-d524fd916dca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周病","subitem_subject_scheme":"Other"},{"subitem_subject":"早産・低体重児出産","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周病原細菌","subitem_subject_scheme":"Other"},{"subitem_subject":"卵膜","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性物質","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"歯周病が早産・低体重児出産に与える影響に関する包括的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯周病が早産・低体重児出産に与える影響に関する包括的研究"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"7677","relation_version_is_last":true,"title":["歯周病が早産・低体重児出産に与える影響に関する包括的研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:19:01.012558+00:00"}