{"created":"2023-07-25T08:08:20.344019+00:00","id":7693,"links":{},"metadata":{"_buckets":{"deposit":"3c94b840-6720-4cad-8204-7f5844b781f0"},"_deposit":{"created_by":18,"id":"7693","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"7693"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00007693","sets":["82:83"]},"author_link":["36759"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-25","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20592207　研究代表者：川畑義裕 (鹿児島大学医学部・歯学部附属病院助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"今回の研究では口腔悪性腫瘍患者の病理組織の免疫染色でP-糖蛋白、Na/K-ATPase、グルコース輸送蛋白、L-アミノ酸輸送蛋白の細胞膜での強い発現が確認された。グルコース輸送蛋白はPET 検査におけるSUV値と明らかな相関を示し、P-糖蛋白、Na/K-ATPase、L-アミノ酸輸送蛋白は腫瘍組織の悪性度、組織分化度、放射性薬品の集積度と明白な相関を示した。これらの結果は動物実験でも同様に高い相関が示された。以上の結果から放射性薬品輸送蛋白は悪性腫瘍で有意に高い発現を示し、腫瘍マーカーとしての可能性が確認された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Expression of transporters of scintigraphic agents on cell membrane was evaluated immunohistochemically using patients with squamous cell carcinoma in oral lesion and animal models with squamous cell carcinoma. Transport proteins of glucose transporter, P-glycoprotein, Na/K-ATPase and L-amino acid transporter found on cell membrane and showed a distinct correlation with tumor malignancy, tissue differentiation and accumulation of nuclear agents in tumor cells. These results indicated a possibility that transport proteins were useful as tumor marker for diagnosis of malignant tumors.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20592207"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川畑, 義裕","creatorNameLang":"ja"},{"creatorName":"KAWABATA, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"36759","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070274842","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"20592207seika.pdf","filesize":[{"value":"301.5 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"20592207seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/7693/files/20592207seika.pdf"},"version_id":"7da31b91-8956-4640-bac8-740cc30db916"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"腫瘍マーカー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"放射性薬品","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"輸送蛋白","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔扁平上皮癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織染色","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"核医学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"核医学における放射性薬品輸送蛋白の腫瘍マーカーとしての可能性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"核医学における放射性薬品輸送蛋白の腫瘍マーカーとしての可能性の検討","subitem_title_language":"ja"},{"subitem_title":"Is transporters of scintigraphic agents useful as tumor makers","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"7693","relation_version_is_last":true,"title":["核医学における放射性薬品輸送蛋白の腫瘍マーカーとしての可能性の検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:14.402559+00:00"}