{"created":"2023-07-25T08:08:20.860257+00:00","id":7705,"links":{},"metadata":{"_buckets":{"deposit":"742115a8-9ffb-4377-be30-296aeec741ce"},"_deposit":{"created_by":18,"id":"7705","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"7705"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00007705","sets":["57:80"]},"author_link":["36790"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-04-15","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20590786　研究代表者：宇都浩文 (鹿児島大学大学院医歯学総合研究科・講師)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"プロテオミクスにより肝細胞の酸化ストレスマーカーの探索を行い、同定したMnSODの血清濃度は非アルコール性脂肪肝炎（NASH）の診断やNASHの肝病態進展の評価に有用であることを明らかにした。また、動物モデルでの検討で、高フルクトース食の方が高脂肪食より脂肪肝の程度は軽度であるものの、肝切除後の肝再生率は低く、肝前癌病変は多数出現した。すなわち、肝再生や肝発癌は肝脂肪化の程度よりは脂肪肝の原因が重要と考えられ、合併する生活習慣病の違いによりNASHの病態やその進展は異なる可能性を明らかにした。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"First of all, we explored the oxidative stress marker(s) using proteomics and identified that MnSOD may be a useful serum biomarker for distinguishing between simple steatotis (SS) and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD). Second, in a rat experimental model, hepatic steatosis (HS) developed in the high fructose diet (H-fruc) group, but was less severe compared to the high fat diet (H-fat) group. In contrast, liver regeneration after 70% partial hepatectomy (PHx) was impaired in the H-fruc group compared to the H-fat and control groups. In addition, the H-fruc group developed a significantly higher incidence of GST-P-positive precancerous lesions compared to the H-fat group. These results indicate that impairment of liver regeneration after PHx and the incidence of precancerous lesions in HS are related to the cause, rather than the degree, of steatosis. Thus, our study demonstrates that serum MnSOD is potential novel marker for NAFLD, and that the pathophysiological condition and progression of NAFLD are potentially affected by different diets.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20590786"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宇都, 浩文","creatorNameLang":"ja"},{"creatorName":"UTO, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"36790","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020347058","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"20590786seika.pdf","filesize":[{"value":"261.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"20590786seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/7705/files/20590786seika.pdf"},"version_id":"b3603740-95cf-4f8c-bef1-8b40585b95be"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NASH","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NAFLD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"MnSOD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"フルクトース","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"肝再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"肝発癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プロテオミクスを用いた非アルコール性脂肪肝炎の診断マーカーの探索と検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロテオミクスを用いた非アルコール性脂肪肝炎の診断マーカーの探索と検証","subitem_title_language":"ja"},{"subitem_title":"Search and validation of diagnostic marker for nonalcoholic steatohepatitis using proteomics","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"7705","relation_version_is_last":true,"title":["プロテオミクスを用いた非アルコール性脂肪肝炎の診断マーカーの探索と検証"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:00.896097+00:00"}