{"created":"2023-07-25T08:08:20.950957+00:00","id":7707,"links":{},"metadata":{"_buckets":{"deposit":"5bb9affa-12ab-4f91-beca-645cc9c691e3"},"_deposit":{"created_by":3,"id":"7707","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7707"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00007707","sets":[]},"author_link":["117963","14879","117964"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clarification of inflammatory reaction of orthodontic tooth movement in MyD88 knockout mice"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"MyD88 ノックアウト マウス オ モチイタ キョウセイガクテキ ハ ノ イドウ ニオケル エンショウヨウ ハンノウ キコウ ノ カイメイ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-30"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20592407　研究代表者：前田綾 (鹿児島大学大学院医歯学総合研究科助教)","subitem_description_type":"Other"},{"subitem_description":"MyD88ノックアウトマウスから単離された骨芽細胞に機械的刺激を負荷した後、ケモカインの発現を解析した。骨芽細胞において、MyD88は機械的刺激によるケモカイン（MIP-2およびMCP-1）の発現と、MAPキナーゼの活性化に関与することが示された。このことから、MyD88は免疫反応だけでなく、機械的刺激による炎症様反応にも関与し、矯正力による歯の移動に重要であることが示唆された。","subitem_description_type":"Other"},{"subitem_description":"In osteoblast isolated from MyD88 knockout mice, chemokine expressions induced by mechanical stress were examined. MyD88 is involved in the gene expression of MIP-2 or MCP-1 and MAP kinase activations by mechanical stresses in osteoblast. These results suggest that MyD88 plays a role not only in immune reactions but also in inflammatory reactions by mechanical stresses and may be important in orthodontic tooth movement.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"マエダ, アヤ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"MAEDA, Aya"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20592407"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前田, 綾"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"20592407seika.pdf","filesize":[{"value":"194.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20592407seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/7707/files/20592407seika.pdf"},"version_id":"e1938446-47f3-4f92-854b-43bfc36c03d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯科矯正学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"MyD88ノックアウトマウスを用いた矯正学的歯の移動における炎症様反応機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MyD88ノックアウトマウスを用いた矯正学的歯の移動における炎症様反応機構の解明"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"7707","relation_version_is_last":true,"title":["MyD88ノックアウトマウスを用いた矯正学的歯の移動における炎症様反応機構の解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:19:00.273126+00:00"}