@misc{oai:ir.kagoshima-u.ac.jp:00000774,
 author = {鮫島, 浩司 and Sameshima, Koji},
 month = {},
 note = {Substance P-like immunoreactivity (SP-LI) of the cerebrospinal fluid was measured by radioimmunoassay in 40 patients with lumbar disch erniation (hernia group)，and in 10 patients with no low back pain and no leg symptoms (control group). The SP-LI was significantly higher in the hernia group (5.49±3.01 pg/ml) than in the control group (2.05±0.52 pg/ml) (p<0.01). In the hernia group，the SP-LI was significantly higher in patients with severe pain in the lower extremities than in those with only mild pain. As the SP-LI was found to be correlated with the severity of pain，it was considered to be au seful index of pain. As for the correlation of SP-LI with the hernia type，the SP-LI wass ignificantly higher in patients with transligamentous extrusion type hernia than in those with protrusion type hernia. This result suggested that the release of substance P was increased with marked compression on the dorsal root., 腰椎椎間板ヘルニア患者40例と腰痛や下肢症状を有さない対照者10例について，脳脊髄液のsubstance P様免疫活性(SP-LI)をradioimmunoassayにより測定した. 腰椎椎間板ヘルニア患者では脳脊髄液中のSP-LI濃度は5.49±3.01pg/mlと対照者の2.05±0.52pg/mlに比べ，有意に高かった(p<0.01). また腰椎椎間板ヘルニア患者において，下肢痛が重篤なほど， SP-LI濃度は有意に高かった. これより脳脊髄液中のSP-LI濃度は疹痛の重症度と相関をもち，疼痛の客観的評価の指標になり得ると考えられた. ヘルニアのタイプとSP-LI濃度との関係は，trans-ligamentous extrusion typeのヘルニアを有するもののSP-LI濃度がprotrusion typeに比べて有意に高かった. これよりヘルニアによる後根の強い圧迫でsubstance Pの放出が増加し，下肢痛が増悪していると考えられた.
医歯学総合研究科博士論文(医学) ; 学位取得日: 平成8年3月15日},
 title = {腰椎椎間板ヘルニアにおける脳脊髄液中のSubstance P},
 year = {1996},
 yomi = {サメシマ, コウジ}
}