{"created":"2023-07-25T08:08:30.899445+00:00","id":7915,"links":{},"metadata":{"_buckets":{"deposit":"90f124c3-d300-4779-97e3-ddc6df4c3d8f"},"_deposit":{"created_by":3,"id":"7915","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"7915"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00007915","sets":["228:230:5130","57:86"]},"author_link":["125197"],"control_number":"7915","item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"76","bibliographicPageStart":"71","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical journal of Kagoshima University","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1991-06-28","subitem_date_issued_type":"Issued"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"1991-06-28"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"The sparse fur with abnormal skin and hair (spf-ash) mouse is a model for the human X linked hereditary disease， ornithine transcarbamylase (OTC) deficiency. It is characterized by hyperammonemia， orotic aciduria， lower serum citrulline and arginine， and delayed hair growth， as noted from its name. Murakami et al. established transgenic mice， which tissue-specifically express rat OTC (rOTC) by introduction of the recombinant DNA carrying 1.3kb of the 5'-flanking region of the gene fused to the rat OTC cDNA into fertilized C57BL mouse eggs. We introduced the rOTC gene into spf-ash mice by mating spf-ash heterozygotes and transgenic mice carrying the rOTC gene. The hemizygous spf-ash mice carrying the rOTC gene showed twice and 6 times higher OTC activities in the liver and small intestine，respectively， than the spf-ash mice, but still about 12% and 27% of the controls. They revealed normal hair growth without sparse fur， normalized urinary orotic acid excretion and serum citrulline and arginine concentration.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"医歯学総合研究科博士論文(医学) ; 学位取得日: 平成3年6月28日","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3087587","subitem_identifier_reg_type":"JaLC"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_5_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://id.ndl.go.jp/bib/000000248051","subitem_relation_type_select":"URI"}}]},"item_5_relation_33":{"attribute_name":"関連（isVersionOf）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dl.ndl.go.jp/info:ndljp/pid/3087587","subitem_relation_type_select":"URI"}}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03685063","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"学位論文題目のタイトル: オルニチン・トラスカルバミラ-ゼ(OTC)欠損(spf・ash)マウスへのOTC遺伝子導入 ; 平成22年度に行われた国立国会図書館の学位論文（博士）デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用（全文複写提供、公衆送信）に供することの許諾を受けたものです（参考：http://www.ndl.go.jp/jp/aboutus/digitization_theses.html）。"}]},"item_5_text_52":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"医研第262号"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 辰彦","creatorNameLang":"ja"},{"creatorName":"シマダ, トキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimada, Tokihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"125197","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"1991-06-28"}],"filename":"000000248051.pdf","filesize":[{"value":"5.0 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"000000248051.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/7915/files/000000248051.pdf"},"version_id":"ddc68a2c-d3d7-43e9-8bc9-9216514790b6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ornithine transcarbamylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transgenic animal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Enzyme deficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Citrulline","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Orotic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"オルニチン・トランスカルバミラーゼ(OTC)欠損(spf-ash)マウスへのOTC遺伝子導入","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オルニチン・トランスカルバミラーゼ(OTC)欠損(spf-ash)マウスへのOTC遺伝子導入","subitem_title_language":"ja"},{"subitem_title":"Introduction of Rat Ornithine Transcarbamylase(OTC) Gene into OTC-deficient, spf-ash, Mice","subitem_title_language":"en"},{"subitem_title":"オルニチン・トランスカルバミラーゼ (OTC) ケッソン (spf-ash) マウス エノ OTC イデンシ ドウニュウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"5","owner":"3","path":["5130","86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-06-03"},"publish_date":"2015-06-03","publish_status":"0","recid":"7915","relation_version_is_last":true,"title":["オルニチン・トランスカルバミラーゼ(OTC)欠損(spf-ash)マウスへのOTC遺伝子導入"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2025-08-29T02:49:49.675430+00:00"}