@article{oai:ir.kagoshima-u.ac.jp:00008093,
 author = {上野, 真一 and UENO, Shinichi and 迫田, 雅彦 and SAKODA, Masahiko and 飯野, 聡 and IINO, Satoshi and 蔵原, 弘 and KURAHARA, Hiroshi and 南, 幸次 and MINAMI, Koji and 安藤, 慶 and ANDOU, Kei and 又木, 雄弘 and MATAKI, Yukou and 喜島, 裕子 and KIJIMA, Yuko and 前村, 公成 and MAEMURA, Kosei and 大脇, 哲弘 and OWAKI, Tetsuhiro and 北薗, 正樹 and KITAZONO, Masaki and 石神, 純也 and ISHIGAMI, Sumiya and 新地, 洋之 and SHINCHI, Hiroyuki and 夏越, 祥次 and NATSUGOE, Shoji},
 issue = {2},
 journal = {鹿児島大学医学雑誌, Medical journal of Kagoshima University},
 month = {Sep},
 note = {It is reported that gross classification of hepatocellular carcinoma (HCC) is associated with tumors’ malignant behavior.
We studied the characteristics and differences between two types of gross classification of HCCs (i.e. Boundary type:
single nodular HCC; Nonboundary type: single nodular with extranodular growth, confluent multinodular, and invasive
HCCs) by using MIB-1 labeling index (LI) and tumor volume doubling time (DT).
　 The DT of 87 HCCs, less than 5 cm in diameter at the start of the observation period, was calculated based on
ultrasonographic images. The natural progression of the lesions were observed during 1 month or more.
Regarding MIB-1 labeling index (LI) of the 87 lesions, we performed immunohistochemical staining (ABC method) with
the MIB-1 monoclonal antibody using paraffin-embedded sections obtained by liver resection. The incidence of micrometastasis in the resected sections and the postoperative recurrence ratio were clearly higher in
the nonboundary type (n=19) than in the boundary type (n=68). MIB-1 LI and DT were 12.1 +/- 1.3% (mean +/- SE) and
274.8 +/- 36.2 days in the boundary type and 14.2 +/- 2.0% and 103.9 +/- 13.4 days in the nonboundary type. A significant
difference of DT was noticed between the 2 groups.
　 These results showed that the nonboundary type HCCs included tumors with rapid growth more than those in the
boundary type. Calculating DT would assist in distinguishing gross classification preinterventionally and in determining
suitable therapy such as liver resection and ablation.},
 pages = {31--35},
 title = {小肝細胞癌の肉眼型分類からみた腫瘍特性 : 細胞増殖能とDoubling Timeの観点から},
 volume = {63},
 year = {2011}
}