{"created":"2023-07-25T08:08:41.170392+00:00","id":8121,"links":{},"metadata":{"_buckets":{"deposit":"ebb81fab-74c7-483c-aa33-2585c1649723"},"_deposit":{"created_by":18,"id":"8121","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8121"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008121","sets":["54:79"]},"author_link":["39043"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-06-12","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(B)))研究成果報告書　課題番号：21310144　研究代表者：杉村和久 (鹿児島大学大学院理工学研究科(工学系)教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"本研究で確立したアミロイドベーター42繊維特異ヒト抗体、B6とB7のエピトープ解析から明らかになったアミロイドベーター42繊維のミミックペプチド、B6-C15を提示するM13ファージをワクチンとして用い、能動免疫によるアルツハイマー認知症の病態マウスモデル(J20)について解析した。その結果、ファージ１匹あたり５分子しか提示されていない状況下（g3p提示）でも、C57BL/Jマウスの皮下検疫により、アミロイドベーター42の繊維および可溶性オリゴマーに反応する特異的抗体が誘導される事を明らかにした。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Bacteriophage evokes strong antibody production by means of innate immunity. Recently, we have established B6 mimotope peptide (B6-C15) which mimics the structure of amyloid ・ 42 (A・) fibril using human single-chain Fv (B6) specific to A・42 fibril. This mimotope peptide binds to A・42 oligomers and inhibits formation of A・42 fibril in vitro. We investigated whether M13 bacteriophage displaying B6-mimotope peptide (B6-C15-phage) could produce A・42 fibril specific antibody response in mice. When mice were immunized i.p. with B6-C15-phage in PBS solution, they produced anti-A・42 fibril specific IgG response in two weeks. This finding suggested a promising vaccination strategy for immunotherapy of Alzheimer’s disease without the involvement of A・42-specific T cell immunity (BBRC 402: 19-22, 2010, and J. Neuroimmunol. 236: 27-38, 2011).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21310144"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉村, 和久","creatorNameLang":"ja"},{"creatorName":"SUGIMURA, Kazuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"39043","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080127240","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21310144seika.pdf","filesize":[{"value":"177.6 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21310144seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/8121/files/21310144seika.pdf"},"version_id":"7cd2e023-d6fa-44d9-b123-33b7253c6380"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アルツハイマー認知症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"M13 ファージ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ワクチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自然免疫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ミミックペプチド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アミロイドベーター","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アルツハイマー認知症のワクチン分子設計に関する基礎研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アルツハイマー認知症のワクチン分子設計に関する基礎研究","subitem_title_language":"ja"},{"subitem_title":"Amyloid beta-42-mimotope displaying M13 bacteriophage for vaccine vehicle of Alzheimer’s disease","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["79"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"8121","relation_version_is_last":true,"title":["アルツハイマー認知症のワクチン分子設計に関する基礎研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-23T02:18:10.160476+00:00"}