{"created":"2023-07-25T08:08:41.803976+00:00","id":8133,"links":{},"metadata":{"_buckets":{"deposit":"19b4d0bd-25e9-47aa-be17-0749b8235fdb"},"_deposit":{"created_by":18,"id":"8133","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8133"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008133","sets":["57:80"]},"author_link":["39082"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21590341　研究代表者：岸田昭世 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"ヒトグリオーマ（神経膠腫）由来の細胞株におけるすべてのWntファミリーの発現を解析し、Wnt-5Aの有意な発現の亢進を認め、Wnt-5A発現亢進がグリオーマの細胞運動、MMP-2発現調節を解して浸潤能を調節していることを見出した。また、がん化に関わる可能性があるHPVやSV40ウイルスを使わずにヒト正常口腔上皮由来細胞MOE1の樹立に成功し、これらの細胞株でWnt-5Aが発現していることを見出した。以上のことから鑑みて、当初の計画以上に進展していると判断している。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We analyzed the expressions of all Wnts and Frizzleds in several human glioma cell lines and found that Wnt-5A, Wnt-7A, Frizzled-2, and Frizzled-6 were highly expressed in those cells. By Wnt-5A-knockdown experiment, we have shown that Wnt-5A stimulated induced cellular motility and invasion of human glioma cells through the induction of MMP-2 mRNA expression and MMP-2 enzymatic activity. We established normal human epithelial cells without using HPV and SV40 genes, which have the potential to induce carcinogenesis.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21590341"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岸田, 昭世","creatorNameLang":"ja"},{"creatorName":"KISHIDA, Shosei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"39082","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050274064","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21590341seika.pdf","filesize":[{"value":"192.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21590341seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/8133/files/21590341seika.pdf"},"version_id":"4a71c277-c54e-4368-bcd2-76fae28fd470"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Wnt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脳腫瘍","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"グリオーマ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔上皮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"不死化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍の病態におけるWntシグナルの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍の病態におけるWntシグナルの役割","subitem_title_language":"ja"},{"subitem_title":"Role of Wnt-5a signaling in tumors","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"8133","relation_version_is_last":true,"title":["腫瘍の病態におけるWntシグナルの役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:06.166330+00:00"}