{"created":"2023-07-25T08:08:42.066977+00:00","id":8139,"links":{},"metadata":{"_buckets":{"deposit":"f9aca717-f152-4fea-9005-d1e249e618de"},"_deposit":{"created_by":18,"id":"8139","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8139"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008139","sets":["57:80"]},"author_link":["39102"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-06-06","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21591920　研究代表者：永野聡 (鹿児島大学大学院医歯学総合研究科助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"癌特異性の高いSurvivinプロモーターに依存して増殖するアデノウイルスベクターを、Osteocalcinプロモーターを用いて骨腫瘍をターゲットとして改良した．このベクターは骨肉腫への治療効果を維持しながら、正常組織への副作用軽減を可能とした．細胞外マトリックスを制御するMatrix Metalloproteinase（MMP）の癌細胞浸潤・転移における役割を明らかにした．骨肉腫におけるヘッジホッグ経路の解析を行い、将来的な骨肉腫の遺伝子治療のターゲットとなることを明らかにした．","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We generated a novel survivin-responsive Surv.m-CRA-OCp, which is regulated by the survivin promoter and cancer/tissue-specific osteocalcin promoter, and demonstrated reduced toxicity to normal tissues, while maintaining its anticancer effects. Significant contribution of matrix-metalloproteinase-14 on vascular invasion and metastasis of breast cancer is shown. We analyzed hedgehog pathway in osteosarcoma and showed that inhibition of GLI2 may represent an effective therapeutic approach for patients with osteosarcoma.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21591920"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永野, 聡","creatorNameLang":"ja"},{"creatorName":"NAGANO, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"39102","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050373139","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21591920seika.pdf","filesize":[{"value":"223.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21591920seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/8139/files/21591920seika.pdf"},"version_id":"5c973c1b-3656-473b-bb1a-f60ac129b656"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子治療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ウイルスベクター","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨軟部腫瘍","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨軟部肉腫に対する新規遺伝子治療法 : 腫瘍内ウイルス拡散をターゲットとして","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨軟部肉腫に対する新規遺伝子治療法 : 腫瘍内ウイルス拡散をターゲットとして","subitem_title_language":"ja"},{"subitem_title":"Novel Strategy of Gene Therapy for Musculoskeletal Sarcoma : Targeting Intratumoral Spread of Viral Vectors","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"8139","relation_version_is_last":true,"title":["骨軟部肉腫に対する新規遺伝子治療法 : 腫瘍内ウイルス拡散をターゲットとして"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:50.476876+00:00"}