{"created":"2023-07-25T08:08:42.110573+00:00","id":8140,"links":{},"metadata":{"_buckets":{"deposit":"5d22667d-2a63-4550-94fd-25d3763ea5a2"},"_deposit":{"created_by":18,"id":"8140","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8140"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008140","sets":["57:80"]},"author_link":["37258"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-04-24","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21592140　研究代表者：堂地勉 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"肥満が骨塩量と関連（正の相関）していることはよく知られている。肥満の骨塩量に及ぼす影響は脂肪組織の重量による荷重効果と脂肪組織由来のエストロゲンなどによる非荷重効果で説明されてきた。内臓と皮下脂肪組織ではそこから分泌されるホルモンの多寡が異なる。脂肪組織由来の液性因子の骨に及ぼす影響は内臓と皮下脂肪組織では異なる可能性がある。躯幹脂肪（皮下脂肪＋内臓脂肪）と末梢脂肪組織（皮下脂肪のみ）を測定し、躯幹脂肪と末梢脂肪組織の骨(左腕)に及ぼす非荷重効果の違いについて検討した。その結果、躯幹脂肪組織が末梢脂肪組織に比べて量的に少ないにもかかわらず、液性因子を介して骨に影響を及ぼすことが判明した。メタボリック症候群で骨が低いという報告がある。今回の検討から、メタボリック症候群では骨は最初には増加するが、進行すると低下していくことが示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Objective: To investigate the non-weight-bearing effect of trunk fat mass (composed of visceral and subcutaneous fat mass) and peripheral fat mass (subcutaneous fat mass alone) on bone mineral density (BMD) in pre- and post-menopausal women.\nMethods: The subjects were 412 pre-menopausal women, 20–50 years of age and 228 post-menopausal women, 50–75 years of age. Age, years since menopause (YSM), height, body weight, and body mass index were recorded. Trunk, peripheral (extremities), left arm (non-weight-bearing site), lean mass, and BMD were measured by dual-energy X-ray absorptiometry. Results: In pre-menopausal women, the amount of trunk fat mass was 6.8 ± 4.1 kg, which was significantly lower than the amount of peripheral fat mass (11.6 ± 3.8 kg, p < 0.001). Although trunk fat mass was positively correlated with arm BMD on Pearson's correlation test, arm lean mass was the only significant predictor of BMD on multiple regression analysis. In post-menopausal women, the amount of trunk fat mass (8.7 ± 3.6 kg) was also significantly lower than the peripheral fat mass (10.3 ± 3.4 kg, p < 0.001). On multiple regression analysis, however, trunk fat mass, but not arm lean mass, was the significant predictor of BMD. In both groups, peripheral fat mass was not correlated with left arm BMD.\nConclusion: The effect of adipocyte-derived biochemical factors on BMD may differ with menopausal status and the sites of adipocyte deposition.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"495","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21592140"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堂地, 勉","creatorNameLang":"ja"},{"creatorName":"DOUCHI, Tsutomu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"37258","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060150413","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21592140seika.pdf","filesize":[{"value":"222.9 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21592140seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/8140/files/21592140seika.pdf"},"version_id":"74b73739-59b5-4b4b-bf0f-7dabf1f64d55"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨塩量","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"内臓脂肪","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"皮下脂肪","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"液性因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エストロゲン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"内臓脂肪と皮下脂肪由来の液性因子の骨塩量に及ぼす非荷重効果の差に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"内臓脂肪と皮下脂肪由来の液性因子の骨塩量に及ぼす非荷重効果の差に関する研究","subitem_title_language":"ja"},{"subitem_title":"Non-weight-bearing effect of trunk and peripheral fat mass on bone mineral density in pre- and post-menopausal women","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"8140","relation_version_is_last":true,"title":["内臓脂肪と皮下脂肪由来の液性因子の骨塩量に及ぼす非荷重効果の差に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:07.808904+00:00"}