{"created":"2023-07-25T08:08:42.243358+00:00","id":8143,"links":{},"metadata":{"_buckets":{"deposit":"bcb9dfaf-81b7-4e0b-ae27-e2e9af9fae44"},"_deposit":{"created_by":3,"id":"8143","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"8143"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008143","sets":[]},"author_link":["39035","117986","117985"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of ultrasound and bubble-liposome-mediated drug delivery to ocular tissues"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"チョウオンパ ト バブル リポソーム オ ツカッタ ヤクブツ ソウタツホウ ノ カイハツ : ガンキュウヨウ チョウオンパ ショウシャ ソウチ ノ カイハツ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-03-30"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究))研究成果報告書　課題番号：21659400　研究代表者：坂本泰二 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_type":"Other"},{"subitem_description":"超音波とバブルリポゾームを組み合わせて、眼組織に薬物・遺伝子送達する方法を開発した。Green fluorescence protein (GFP)遺伝子をバブルリポゾームに包埋して、眼表面・眼内に注入し、超音波を局所照射した所、結膜や網膜の意図した部に限局した遺伝子導入が可能であった。特に、ミュラー細胞への遺伝子導入が優れていた。適切なパワーで、照射部位の組織傷害を最小にすることが可能であった。超音波端子は心臓カテーテルで用いるものを改良したものが効果的であった。","subitem_description_type":"Other"},{"subitem_description":"We developed a novel method to deliver genes or drugs to ocular tissues using ultrasound and bubble-liposome. GFP cDNA embedded in bubble-liposome was injected in the vitreous followed by irradiation of ultrasound.\nGFP was strongly expressed by retina where ultrasound was irradiated. Tissue damage was minimal. We also developed a new ultrasound probe for that.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"サカモト, タイジ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"SAKAMOTO, Taiji"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"496","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21659400"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂本, 泰二"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"21659400seika.pdf","filesize":[{"value":"306.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21659400seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/8143/files/21659400seika.pdf"},"version_id":"d740ae9d-e1a7-41de-be63-30c500940e2c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"超音波","subitem_subject_scheme":"Other"},{"subitem_subject":"ナノバブル","subitem_subject_scheme":"Other"},{"subitem_subject":"リポソーム製剤","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"超音波とバブルリポソームを使った薬物送達法の開発 : 眼球用超音波照射装置の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"超音波とバブルリポソームを使った薬物送達法の開発 : 眼球用超音波照射装置の開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-25"},"publish_date":"2014-12-25","publish_status":"0","recid":"8143","relation_version_is_last":true,"title":["超音波とバブルリポソームを使った薬物送達法の開発 : 眼球用超音波照射装置の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:19:55.409932+00:00"}