{"created":"2023-07-25T08:08:42.506176+00:00","id":8149,"links":{},"metadata":{"_buckets":{"deposit":"83b44247-22c4-424b-bb6d-65f8917518d9"},"_deposit":{"created_by":3,"id":"8149","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"8149"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008149","sets":[]},"author_link":["117989","12858","117990"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Forensic diagnosis of abuse and determining the duration based on the changes of nervous・endocrine・immune systems by the stress"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ストレス ニヨル シンケイ・ナイブンピツ・メンエキケイ ノ ヘンカ ニ モトズク ギャクタイ ノ シンダン オヨビ キカン スイテイホウ ノ カクリツ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-03-31"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書　課題番号：22790599　研究代表者：林敬人 (鹿児島大学大学院医歯学総合研究科講師)","subitem_description_type":"Other"},{"subitem_description":"心理的虐待の動物モデルである長期拘束ストレスマウス及び小児虐待死剖検例において，視床下部－下垂体－副腎皮質系（HPA axis）の変動を解析した。動物実験，剖検例いずれも比較的短期間のストレスでは，糖質コルチコイドを産生するため副腎が肥大し，副腎内コレステロールが減少し，副腎へのコレステロール供給に関わるSR-BI, HMGR, HSLの副腎内の発現が増加していた。以上の結果から，副腎内分泌系の変動を解析することは小児虐待の法医病理学的診断及び虐待期間推定の指標となり得る可能性が示唆された。","subitem_description_type":"Other"},{"subitem_description":"We examined changes in the hypothalamic-pituitary-adrenal (HPA) axis in a mouse restraint stress model of psychological abuse and in autopsy cases to determine a possible indicator for the diagnosis of child abuse. Both results of animal experiments and autopsy samples indicate that stress including abuse for relatively short periods causes adrenal hypertrophy due to the overproduction of glucocorticoids, decrease of adrenal cholesterol which is material for glucocorticoids, and increase of adrenal gene expression of SR-BI, HMGR and HSL that are related to cholesterol supply to the glands.\nOur results suggest that the analysis of the HPA axis may be useful for the diagnosis of child abuse and determining the duration.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ハヤシ, タカヒト"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"HAYASHI, Takahito"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"498","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"22790599"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 敬人"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"22790599seika.pdf","filesize":[{"value":"276.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22790599seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/8149/files/22790599seika.pdf"},"version_id":"05a3c388-33bd-4fc2-bb7c-0f362d1fd602"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"児童虐待","subitem_subject_scheme":"Other"},{"subitem_subject":"長期拘束ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"視床下部－下垂体－副腎皮質系","subitem_subject_scheme":"Other"},{"subitem_subject":"糖質コルチコイ ド","subitem_subject_scheme":"Other"},{"subitem_subject":"副腎内コレステロール","subitem_subject_scheme":"Other"},{"subitem_subject":"副腎髄質系","subitem_subject_scheme":"Other"},{"subitem_subject":"法医病理学的診断","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ストレスによる神経・内分泌・免疫系の変化に基づく虐待の診断及び期間推定法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ストレスによる神経・内分泌・免疫系の変化に基づく虐待の診断及び期間推定法の確立"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"8149","relation_version_is_last":true,"title":["ストレスによる神経・内分泌・免疫系の変化に基づく虐待の診断及び期間推定法の確立"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:19:55.893430+00:00"}