{"created":"2023-07-25T08:08:42.770638+00:00","id":8155,"links":{},"metadata":{"_buckets":{"deposit":"dd57cd85-fb5d-44ee-ae5b-693f5fc8af76"},"_deposit":{"created_by":18,"id":"8155","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8155"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008155","sets":["57:80"]},"author_link":["6518"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-04-25","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2011年度科学研究費助成事業(科学研究費補助金(研究活動スタート支援))研究成果報告書　課題番号：23890166　研究代表者：伊藤隆史 (鹿児島大学大学院医歯学総合研究科特任講師)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"敗血症の際には、核内タンパク質ヒストンが細胞外に放出され、血中のヒストン値が上昇することが報告されているが、今回我々はマウスを用い、血中のヒストン値が上昇すると、肺に血栓が形成され、末梢血血小板数が減少し、凝固時間が延長し、出血傾向を示すようになり、播種性血管内凝固症候群 (DIC) とよく似た病態に陥ることを明らかにした。さらには、近年、DIC治療薬として認可されたリコンビナントトロンボモジュリン製剤はヒストンと結合し、ヒストンによる DIC様の病態を改善しうることを見いだした。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Histones, abundant proteins in the nucleus, are released into the extracellular space during sepsis. In this study we found that extracellular histones triggered platelet aggregation, leading to thrombotic occlusion of pulmonary capillaries in mice. These mice displayed signs of disseminated intravascular coagulation (DIC), including thrombocytopenia, prolonged prothrombin time, decreased fibrinogen, fibrin deposition\nin capillaries, and bleeding symptoms. Recombinant thrombomodulin, a newly approved drug for DIC in Japan, prevented histone-mediated platelet aggregation and protected mice against histone-induced fatal thromboembolism.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"492","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23890166"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 隆史","creatorNameLang":"ja"},{"creatorName":"ITO, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6518","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020381171","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23890166seika.pdf","filesize":[{"value":"658.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23890166seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/8155/files/23890166seika.pdf"},"version_id":"95a3f44c-41f8-4d2f-ba6c-64ec7290a243"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DAMPs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"血栓形成","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"敗血症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"DIC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒストン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"トロンボモジュリン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DIC治療の新規分子標的としてのDAMPs群","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DIC治療の新規分子標的としてのDAMPs群","subitem_title_language":"ja"},{"subitem_title":"DAMPs : novel molecular targets for DIC therapy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"8155","relation_version_is_last":true,"title":["DIC治療の新規分子標的としてのDAMPs群"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:46.761061+00:00"}