{"created":"2023-07-25T08:09:08.424883+00:00","id":8648,"links":{},"metadata":{"_buckets":{"deposit":"91accc83-453c-464a-a0b1-9ad2a887d6d2"},"_deposit":{"created_by":3,"id":"8648","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"8648"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008648","sets":[]},"author_link":["112829","7607","112830"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Challenge to cancer therapy and visualization with magnetic nanoparticles by pulsing alternating-current magnetic fields"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"コウリュウ ジバ ノ パルスカ ニヨル ジセイ ナノ リュウシ オ モチイタ ガン ノ チリョウ ガゾウカ エノ チョウセン"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-06-14"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究)研究成果報告書　課題番号：23655204　研究代表者：楠元芳文(鹿児島大学・大学院理工学研究科・教授)","subitem_description_type":"Other"},{"subitem_description":"粒子の大きさがnm（1nmは１０億分の１m）程度の微粒子をナノ粒子、それらの複合体をナノコンポジットと呼ぶ。種々の磁性ナノ粒子（酸化鉄など）やナノコンポジット（金―酸化鉄など）を合成し，これらの適量とヒーラがん細胞（ヒト子宮頸部がん細胞）を含む培地に連続またはパルス状交流磁場を印加させると共に可視光照射の併用も実施し，温度を上昇させてがん細胞を死滅させることが出来た。磁性ナノ粒子を含む水溶液にパルス交流磁場を印加し、音波検出に対する今後の課題を明らかにできた。","subitem_description_type":"Other"},{"subitem_description":"Hyperthermia is a cancer treatment modality that destroys tumors by elevating the temperature of the cancerous tissue to around 43 °C. Then, we synthesized the magnetic nanoparticles like Fe3O4, γ-Fe2O3 and α-Fe2O3 with different sizes and shapes and nanocomposites with core-shell structures like Au-Fe3O4 and Fe3O4-TiO2. We studied the cancer cell killing effects under three distinct conditions, a) only CW or pulsed alternating-current (AC) magnetic-field induction, b) only photoirradiation and c) combined CW or pulsed AC magnetic-field induction and photoirradiation conditions. For HeLa cancer cells adopted as a model to investigate the thermal-photocatalytic cancer cell killing efficiency of as-synthesized nanomaterials, almost 100% cancer cells were destructed under combined (CW or pulsed) AC magnetic-field induction and photoirradiation conditions. We got fruitful information on the sound-waves detection induced by pulsed AC magnetic-fields for aqueous solution including magnetic nanoparticles.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"クスモト, ヨシフミ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"KUSUMOTO, Yoshifumi"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"430","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23655204"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楠元, 芳文"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23655204.pdf","filesize":[{"value":"217.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23655204.pdf","url":"https://ir.kagoshima-u.ac.jp/record/8648/files/23655204.pdf"},"version_id":"2f10c47a-037c-4386-8e84-24a5eb0f143e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"交流磁場","subitem_subject_scheme":"Other"},{"subitem_subject":"磁性ナノ粒子","subitem_subject_scheme":"Other"},{"subitem_subject":"がんの治療","subitem_subject_scheme":"Other"},{"subitem_subject":"ハイパーサーミア","subitem_subject_scheme":"Other"},{"subitem_subject":"パルス状交流磁場","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒーラ細胞（ヒト子宮頸部がん細胞）","subitem_subject_scheme":"Other"},{"subitem_subject":"ナノ複合体","subitem_subject_scheme":"Other"},{"subitem_subject":"音波の発生と検出","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"交流磁場のパルス化による磁性ナノ粒子を用いたがんの治療・画像化への挑戦","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"交流磁場のパルス化による磁性ナノ粒子を用いたがんの治療・画像化への挑戦"}]},"item_type_id":"8","owner":"3","path":["79"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"8648","relation_version_is_last":true,"title":["交流磁場のパルス化による磁性ナノ粒子を用いたがんの治療・画像化への挑戦"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:15:41.298615+00:00"}