{"created":"2023-07-25T08:09:08.700714+00:00","id":8654,"links":{},"metadata":{"_buckets":{"deposit":"fedce0f6-55bf-4e5d-867c-9826868ad204"},"_deposit":{"created_by":18,"id":"8654","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"8654"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008654","sets":["82:83"]},"author_link":["42044"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(若手研究(B))研究成果報告書　課題番号：23791912　研究代表者：牧瀬高穂(鹿児島大学・医学部・歯学部附属病院・医員)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"初期療法を施行することで鼻粘膜擦過細胞中のヒスタミンH1受容体mRNAの発現量は有意に低下することが確認された。スギ花粉飛散開始前の鼻粘膜擦過細胞中のヒスタミンH1受容体mRNA発現量と、スギ花粉飛散時期の鼻症状に、正の相関関係があることを見出した。マウスにスギ花粉エキスを反復投与することで、くしゃみや鼻掻きの鼻症状を有意に誘導し、血清中スギ花粉特異的IgEが産生されることを確認した。ヒト鼻粘膜上皮培養細胞にヒスタミン受容体が発現していることを確認できた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"It was confirmed that the expression level of histamine H1 receptor mRNA in nasal mucosa was reduced significantly by the enforcement of primal therapy. We found that there was a positive correlation histamine H1 receptor mRNA expression level of nasal mucosa before the start of the pollen dispersal and nasal symptoms in pollen dispersal season. By repeating administration of cedar pollen extract in mice, it was confirmed that significantly induced nasal symptoms of scratching and nose sneezing, serum cedar pollen-specific IgE was produced. I was able to confirm that the histamine receptor was expressed in human nasal epithelial cell culture.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"496","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23791912"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"牧瀬, 高穂","creatorNameLang":"ja"},{"creatorName":"MAKISE, Takao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42044","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030585120","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23791912.pdf","filesize":[{"value":"189.9 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23791912.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/8654/files/23791912.pdf"},"version_id":"63855421-e47c-46ff-89db-03bb62ffe02f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アレルギー性鼻炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"スギ花粉症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒスタミンH1 受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"鼻過敏症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"スギ花粉症初期療法が鼻粘膜ヒスタミンH1受容体発現に及ぼす効果と機序に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"スギ花粉症初期療法が鼻粘膜ヒスタミンH1受容体発現に及ぼす効果と機序に関する研究","subitem_title_language":"ja"},{"subitem_title":"The mechanism and effect of primal therapy and nasal histamine H1 receptor in Japanese cedar pollinosis.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"8654","relation_version_is_last":true,"title":["スギ花粉症初期療法が鼻粘膜ヒスタミンH1受容体発現に及ぼす効果と機序に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:24.704017+00:00"}