{"created":"2023-07-25T08:09:24.277280+00:00","id":8989,"links":{},"metadata":{"_buckets":{"deposit":"bc946463-8f21-4563-a312-8bd6bda49a2c"},"_deposit":{"created_by":29,"id":"8989","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"8989"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00008989","sets":["172:206"]},"author_link":["42945"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-12","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（B））研究成果報告書　課題番号：23390337　研究代表者：佐原寿史（鹿児島大学・医用ミニブタ・先端医療開発研究センター・准教授）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"ブタをドナーとする異種移植は、ドナー臓器不足に対する有力な解決策となる。腎臓や心臓では2か月超える異種臓器の生着が得られる一方、異種肺移植の生着は数時間から数日に留まる。本研究では、ブタ肺をヒト血液で灌流するex-vivoモデルやカニクイザルへ同所性左肺移植を行うモデルによって、GalT-KOブタ肺が超急性期の肺機能不全を回避しうること、ドナーへの一酸化炭素投与による血管内皮保護効果を介して、術後微小血管障害軽減が得られた。しかし異種移植肺は術後3日以内に血栓性微小血管障害による機能不全を呈したことから、長期効果を得るためには新たな遺伝子改変ブタを用いた治療方針の開発が望まれる結果となった。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"The results of both heart and kidney  GalT-K0 swine-to-primate studies have been more encouraging than for lung xenotransplantation. This may be because research in pulmonary xenotransplantation is limited. Here, we evaluated 1) whether  GalT-K0 lungs could prevent hyper-acute pulmonary xenograft dysfunction using ex-vivo lung perfusion or in-vivo orthotopic left lung transplant model and 2) the effect of carbon monoxide (CO) on reducing the development of microangiopathy (CO-treated animals).  GalT-K0 lungs exhibited stable pulmonary function compared with wild-type lungs when perfused with human blood in an ex-vivo perfusion model, which was confirmed by the in-vivo transplant model. Although, thrombotic micro angiopathy ultimately developed in all grafts of the CO-treated animals, the degree of microangiopathy was reduced in these animals. Reduction of the innate immune response by CO treatment would be one of the the rapeutic strategies for prolonging pulmonary xenograft survival.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23390337"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐原, 寿史","creatorNameLang":"ja"},{"creatorName":"SAHARA, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42945","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090452333","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2014-06-12"}],"filename":"23390337_佐原寿史.pdf","filesize":[{"value":"209.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23390337_佐原寿史.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/8989/files/23390337_佐原寿史.pdf"},"version_id":"6b6a8e18-de8a-445c-9ecd-472dbbc7f9fa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"トランスレーショナルリサーチ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"異種肺移植","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"GalT-KOブタ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"カニクイザル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化炭素","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"急性肺機能不全","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ドナー臓器保護作用に基づく大動物移植肺生着延長戦略 : 同種移植から異種移植への展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ドナー臓器保護作用に基づく大動物移植肺生着延長戦略 : 同種移植から異種移植への展開","subitem_title_language":"ja"},{"subitem_title":"Attenuation of hyperacute dysfunction and coagulopathy in GalT-KO pulmonary xerotransplantation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["206"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-19"},"publish_date":"2015-05-19","publish_status":"0","recid":"8989","relation_version_is_last":true,"title":["ドナー臓器保護作用に基づく大動物移植肺生着延長戦略 : 同種移植から異種移植への展開"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-07-18T02:16:50.838738+00:00"}