{"created":"2023-07-25T08:09:25.018741+00:00","id":9006,"links":{},"metadata":{"_buckets":{"deposit":"3c97782e-0197-408c-998d-8171b8483838"},"_deposit":{"created_by":3,"id":"9006","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9006"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00009006","sets":[]},"author_link":["2140","118031","118032"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Search of organ specific tumor makers by N-glycan expression"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"Nガタ トウサ オ モチイタ ゾウキ トクイテキ シュヨウ マーカー ノ カイハツ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-11"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2012-2013年度科学研究費助成事業（挑戦的萌芽研究）研究成果報告書　課題番号：24659618　研究代表者：夏越祥次（鹿児島大学・医歯（薬）学総合研究科・教授）","subitem_description_type":"Other"},{"subitem_description":"健常者11検体と食道がん患者63検体をGlycoModも用いて糖鎖構造の中から18糖鎖を選択した。これらの18糖鎖による多変量解析を行い、有意差が認められた糖鎖を4つ抽出した。このうち3つは、過去に行ったMALDI-TOF-MSで抽出された糖鎖構造と一致し、新たに1つの糖鎖が発見された。これらの糖鎖は食道癌に特異的で精度の高い糖鎖マーカーとして利用できると考えられた。また、健常者群と膵臓癌患者群間で、両者の層別化が可能な発現糖鎖が9つ抽出可能であった。4個の候補糖鎖で有意差が認められ、再現性が確認された。膵臓癌に特異的な糖鎖マーカーとしてさらに症例を増やして検討する必要がある。","subitem_description_type":"Other"},{"subitem_description":"We analyzed the serum  N-glycan by Profiling Solution in 63 esophageal cancer patients and 11 healthy volunteers. We selected 18  N-glycan by GlycoMod method. When performing by multivariate analysis in these N-glycan, 4 glycan had a significant difference. Three of these four N-glycan was in accord with structure of N-glycan which was previously extracted by MALDI-TOF-MS method. Thus new one N-glycan was found. These N-glycans are useful markers to detect esophageal cancer. In pancreas cancer, we found 9 N-glycans which was stratified between esophageal cancer patients and healthy volunteers. In four of these 9 N-Glycans, significant difference was identified. We should collect many cases and analyze the useful markers for detection of pancreas cancer.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ナツゴエ, ショウジ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NATSUGOE, Shoji"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"24659618"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"夏越, 祥次"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"24659618_夏越祥次.pdf","filesize":[{"value":"203.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24659618_夏越祥次.pdf","url":"https://ir.kagoshima-u.ac.jp/record/9006/files/24659618_夏越祥次.pdf"},"version_id":"419f9f36-6ec6-419b-9d09-3f378a9db24c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"消化器癌","subitem_subject_scheme":"Other"},{"subitem_subject":"N結合型連鎖","subitem_subject_scheme":"Other"},{"subitem_subject":"食道癌","subitem_subject_scheme":"Other"},{"subitem_subject":"膵臓癌","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"N型糖鎖を用いた臓器特異的腫瘍マーカーの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"N型糖鎖を用いた臓器特異的腫瘍マーカーの開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-21"},"publish_date":"2015-05-21","publish_status":"0","recid":"9006","relation_version_is_last":true,"title":["N型糖鎖を用いた臓器特異的腫瘍マーカーの開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:19:04.504048+00:00"}