{"created":"2023-07-25T08:09:25.283601+00:00","id":9012,"links":{},"metadata":{"_buckets":{"deposit":"c4bddde8-8708-475d-ae9a-8eea72ffb50e"},"_deposit":{"created_by":3,"id":"9012","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"9012"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00009012","sets":[]},"author_link":["118042","118041","43002"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Therapy targeting folate beta expressing macrophages in chronic inflammation"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ヨウサン リセプター ベータ ハツゲン カッセイカ マクロファージ オ ヒョウテキ トシタ マンセイ エンショウ ノ チリョウヤク ノ カイハツ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-14"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23591441　研究代表者：松山隆美（鹿児島大学・医歯（薬）学総合研究科・教授）","subitem_description_type":"Other"},{"subitem_description":"抗葉酸リセプターβイムノトキシン関節内投与によるメチル化BSA誘発関節炎の治療効果を示した。さらに静脈注射によるブレオマイシン誘発強皮症の線維化抑制を皮膚の肥厚、ハイドロキシプロリン量の減少により明らかにした。また、皮膚線維化部位に早期に浸潤するマクロファージは葉酸リセプターβ発現、TGFβ産生細胞であり、イムノトキシンの投与はこれらのマクロファージ数を減少させた。このモデルでの線維化抑制の機構としてイムノトキシンによるCTGF産生の抑制は早期では明らかでないことから、TGFβ産生マクロファージの減少の結果、CTGF産生を産生する繊維芽細胞が減少することが示唆された。","subitem_description_type":"Other"},{"subitem_description":"We assessed the antiarthrogenic and the antifibrotic effects ofdepletion of FRbeta-expressing macrophages in methylated BSA induced arthritis and bleomycin induced skin fibrosis models using a recombinant immunotoxin to FRbeta, respectively. Skin fibrosis was evaluated by the change of skin thickness and hydroxyproline content on Day 29. The TGFbetal mRNA levels in the treated skin were assessed by quantitative real-time RT-PCR on Day 9. Anti-FRbeta-PE38 treatment led to a dramatic reduction in the number of FRbeta-expressing macrophages. Additionally, skin thickness and hydroxyproline content, were markedly reduced. TGFbetal mRNA levels were also down-regulated after the treatment. TGFbetal expression was enriched in FRbeta-expressing macrophages compared with FRbeta-negative macrophages. Anti-FRbeta-PE38 treatment efficiently depleted FRbeta-expressing macrophages and consequently alleviated BLM-induced skin fibrosis.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"マツヤマ, タカミ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"MATSUYAMA, Takami"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23591441"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松山, 隆美"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"23591441_松山隆美.pdf","filesize":[{"value":"135.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23591441_松山隆美.pdf","url":"https://ir.kagoshima-u.ac.jp/record/9012/files/23591441_松山隆美.pdf"},"version_id":"a255cf8f-9e73-4d22-b7cc-6c03414e7c89"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"葉酸リセプター","subitem_subject_scheme":"Other"},{"subitem_subject":"イムノトキシン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"葉酸リセプターベータ発現活性化マクロファージを標的とした慢性炎症の治療薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"葉酸リセプターベータ発現活性化マクロファージを標的とした慢性炎症の治療薬の開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"9012","relation_version_is_last":true,"title":["葉酸リセプターベータ発現活性化マクロファージを標的とした慢性炎症の治療薬の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:52.889197+00:00"}