@article{oai:ir.kagoshima-u.ac.jp:00009197,
 author = {北野, 元生 and KITANO, Motoo and 波多野, 浩道 and HATANO, Hiromichi},
 journal = {鹿児島大学歯学部紀要},
 month = {Mar},
 note = {The genetic background in relation to the susceptibility to experimental oral carcinogenesis in rats was reviewed. As an experimental model, 4-nitroquinoline 1-oxide (4 NQO)-induced rat carcinoma is thought to be excellent. Because it demonstrates obvious organtropic, species and straas specificity in its carcinogenesis. Administration of 4 NQO-solution as drinking water produces oral carcinomas in rats with a high incidence. We described strain differences on susceptibility to 4 NQO-induced rat carcinoma especially of the tongue concerning 1) enzymal activity of 4 NQO metabolism, 2) 4-hydroxyaminoquinoline 1-oxide (4 HAQO)-DNA adduct formation (4 HAQO is the proximate carcinogenic derivative from 4 NQO), 3) DNA repair processes, and 4) immunological response comparing various strains of rats, to clarify the genetic controls on the experimental carcinogenesis in rats.},
 pages = {35--55},
 title = {実験的ラット口腔癌発生におよぼす遺伝的要因 : 付・4NQO誘発ラット口腔癌について},
 volume = {11},
 year = {1991}
}