{"created":"2023-07-25T08:10:04.592108+00:00","id":9835,"links":{},"metadata":{"_buckets":{"deposit":"43bc2d9a-4530-43fb-a17e-8bad6ecf26c6"},"_deposit":{"created_by":18,"id":"9835","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"9835"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00009835","sets":["57:78"]},"author_link":["117227","117228"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"137","bibliographicPageStart":"125","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Dendritic cells","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1994-01-01","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"This study aimed to see HTLV-1 infection in 277 cases of malignant lymphoma (ML) in a HTLV-1indemic area by means of ISH employing a highly biotinylated concatamer probe synthesized by a couple of primers SK43 and 44 PCR for HTLV-1 provial DNA pX Tax region. The MLs comprised 115 T-cell MLs, 73 B-cell MLs, 14 Hodgkin's disease (HD) and MLs from the age group less than 20 years old (y.o.). The non-Hodgkin's MLs were categorized according to updated Kiel classification. ISH detected a signal of HTLV-1 proviral DNA including pX Tax region, showing positive stain dominantly in cytoplasm of lymphoma cells and non-neoplastic cells including intermingling small 1ymphocytes, histiocytes and epithelioid cells. ML in which lymphoma cells showed the signal was defined as \"\"HTLV-1-related ML\"\". And ML in which any cells revealed the signal was defined as \"\"HTLV-1-carrier ML\"\". HTLV-1-related MLs were found in all the subtypes of T-cell MLs (69/115, 60%), indicating its high rate (44/45, 97.8%) in T-cell pleomorphic lymphoma with histological features of adult T-cell leukemia/ lymphoma (ATLL). Even in MLs other than the T-cell MLs, HTLV-1ielated MLs were noted in 21 (29%) of B-cell MLs, 8 (57%) of HD and 4 (16%) of MLs from the age group less than 20 y.o.. HTLV-1-carrier MLs were found in 93 (81%) of T-cell MLs, 35 (49%) of B-cell MLs, 8 (57%) of HD, 13 \n(52%) of MLs from the age group less than 20 y.o.. HTLV-1-related T-cell MLs in which many lymphoma cells showed the signal may be ATLL, but it was unknown whether there were ATLLs in the ISH-negative cases and in HTLV-1-carrier MLs other than HTLV-1ielated MLs. Considering several technical problems in this ISH, the followings were suggested in this study. HTLV-1 may have oncogenetic effect(s) specific for ATLL and non-specific for MLs other than ATLL but ATLL development would need factor(s) other than HTLV-1 infection. There may be HTLV-1-related B-cell MLs and HD. Some of patients with B-cell MLs and in the under 20-year-old ML patients would fail to produce antibodies against HTLV-1, because higher HTLV-1 carrier rates in these patients were recognized in this study than in the serovirological studies.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"日本樹状細胞研究会","subitem_publisher_language":"ja"},{"subitem_publisher":"Japanese Dendritic Cells Society","subitem_publisher_language":"en"}]},"item_6_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11039557","subitem_source_identifier_type":"NCID"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_6_subject_20":{"attribute_name":"NIIsubject","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasui, Kazuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Eiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"DC(Hasui)1994.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DC(Hasui)1994.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/9835/files/DC(Hasui)1994.pdf"},"version_id":"16aa7bcc-36a5-4140-8104-e0746214cacc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human T-cell leukemia virus type 1(HTLV-1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Malignant lymphomas","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1 endemic area","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"In-situ-hybridization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-l pX Tax","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region","subitem_title_language":"en"}]},"item_type_id":"6","owner":"18","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-04-13"},"publish_date":"2010-04-13","publish_status":"0","recid":"9835","relation_version_is_last":true,"title":["Human T-cell leukemia virus type 1(HTLV1) infection in malignant lymphomas in a HTLV1-endemic area, Kagoshima, Japan : HTLV-1 in-situ-hybridization (ISH) analysis employing a highly biotinylated concatamer probe synthesized by polymerase chain reaction (PCR) for HTLV-1 proviral DNA pX Tax region"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-02-07T06:20:00.936562+00:00"}