@article{oai:ir.kagoshima-u.ac.jp:00009872,
 author = {野口, 和行 and NOGUCHI, Kazuyuki},
 journal = {鹿児島大学歯学部紀要},
 month = {Mar},
 note = {It is clear that prostanoids including prostaglandin E2 (PGE2) are involved in the pathogenesis ofperiodontal diseases, because a lot of studies have indicated that in animal models and humans traditional nonsteroidal anti-inflammatory drugs inhibit progression of the diseases. Recent researches have shown that cyclooxygenase-2, which is an inducible prostaglandin-endoperoxide synthase in response to proinflammatory molecules, plays a crucial role in prostaglandin production in periodontal lesions. Monocytes/macrophages, gingival fibroblasts and periodontal ligament cells can produce PGE2 via cyclooxygense-2 after stimulation with interleukin-1, tumor necrosis factor a and lipopolysaccharides. PGE2 exerts a variety of pro-inflammatory actions including osteoclast formation. Furthermore, selective cyclooxygenase-2 inhibitors are as efficacious as traditional nonsteroidal anti-inflammatory drugs for inhibition of progression of periodontal diseases in animal models. Therefore, cyclooxygenase-2 inhibitors may be effective for a host modulatory therapy of periodontal diseases, but clinical studies with great care are necessary to prove it, based on the understanding of the advantages and disadvantages of cyclooxygenase-2 inhibitors.},
 pages = {39--48},
 title = {歯周病とプロスタグランジン},
 volume = {28},
 year = {2008}
}