{"created":"2023-07-25T08:10:06.164746+00:00","id":9872,"links":{},"metadata":{"_buckets":{"deposit":"e812ff92-ef12-4f04-bca0-19ba577488b5"},"_deposit":{"created_by":18,"id":"9872","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"9872"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00009872","sets":["228:274:4807","64:65"]},"author_link":[],"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-26","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"48","bibliographicPageStart":"39","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"鹿児島大学歯学部紀要","bibliographic_titleLang":"ja"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-03-26","subitem_date_issued_type":"Issued"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"It is clear that prostanoids including prostaglandin E2 (PGE2) are involved in the pathogenesis ofperiodontal diseases, because a lot of studies have indicated that in animal models and humans traditional nonsteroidal anti-inflammatory drugs inhibit progression of the diseases. Recent researches have shown that cyclooxygenase-2, which is an inducible prostaglandin-endoperoxide synthase in response to proinflammatory molecules, plays a crucial role in prostaglandin production in periodontal lesions. Monocytes/macrophages, gingival fibroblasts and periodontal ligament cells can produce PGE2 via cyclooxygense-2 after stimulation with interleukin-1, tumor necrosis factor a and lipopolysaccharides. PGE2 exerts a variety of pro-inflammatory actions including osteoclast formation. Furthermore, selective cyclooxygenase-2 inhibitors are as efficacious as traditional nonsteroidal anti-inflammatory drugs for inhibition of progression of periodontal diseases in animal models. Therefore, cyclooxygenase-2 inhibitors may be effective for a host modulatory therapy of periodontal diseases, but clinical studies with great care are necessary to prove it, based on the understanding of the advantages and disadvantages of cyclooxygenase-2 inhibitors.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0389-7834","subitem_source_identifier_type":"PISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0035442X","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野口, 和行","creatorNameLang":"ja"},{"creatorName":"NOGUCHI, Kazuyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"28-11.pdf","filesize":[{"value":"129.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"28-11.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/9872/files/28-11.pdf"},"version_id":"d9c83bc9-5b34-4a8c-834a-0fb822e628ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"periodontal disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prostanoid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prostaglandin E2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclooxygenase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"歯周病とプロスタグランジン","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯周病とプロスタグランジン","subitem_title_language":"ja"},{"subitem_title":"Periodontal diseases and prostaglandins","subitem_title_language":"en"}]},"item_type_id":"7","owner":"18","path":["65","4807"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-13"},"publish_date":"2015-01-13","publish_status":"0","recid":"9872","relation_version_is_last":true,"title":["歯周病とプロスタグランジン"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-26T07:09:18.563609+00:00"}