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新規脂肪肝関連分子Vanin-1の機能解析
http://hdl.handle.net/10232/19842
http://hdl.handle.net/10232/198421e61ceff-8eb8-44d6-bb2d-f8a46d84ec96
名前 / ファイル | ライセンス | アクション |
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Item type | 研究報告書 / Research Paper(1) | |||||
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公開日 | 2013-10-01 | |||||
タイトル | ||||||
タイトル | 新規脂肪肝関連分子Vanin-1の機能解析 | |||||
タイトルよみ | ||||||
タイトルよみ | シンキ シボウカン カンレン ブンシ Vanin-1 ノ キノウ ブンセキ | |||||
別言語のタイトル | ||||||
その他のタイトル | Analysis of vanin-1 in non-alcoholic fatty liver disease | |||||
著者 |
吉崎, 隆之
× 吉崎, 隆之 |
|||||
著者よみ | ||||||
姓名 | ヨシザキ, タカユキ | |||||
別言語の著者 | ||||||
姓名 | YOSHIZAKI, Takayuki | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2011-2013年度科学研究費助成事業(科学研究費補助金(若手研究(B))研究成果報告書 課題番号:23790799 研究代表者:吉崎隆之(鹿児島大学産学官連携推進センター特任講師) | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 本研究では高脂肪食を与えたマウス肝臓および培養液に遊離脂肪酸を添加したヒト肝癌由来細胞株のVanin-1 mRNA発現量変化を調べ,そのメカニズムを考察した.動物実験ではVanin-1 mRNAは高脂肪食に替えて僅か1日後には発現が亢進した.培養細胞を使った実験では脂肪滴の形成しない低オレイン酸濃度でもVanin-1 mRNAの発現が亢進した.様々な脂肪酸を用いて検討した結果,肝臓に脂肪滴を作りやすいオレイン酸,リノール酸でVanin-1が発現誘導されることが分かった. | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | We analyzed the expression of hepatic vanin-1 mRNA following the administration of a high-fat diet in mice as well as free fatty acids in hepatocyte cultures and speculated its possible mechanism. Vanin-1 mRNA levels in the livers of mice were upregulated within a day of the high-fat diet. An in vitro analysis using HuH-7 cells revealed a significant upregulation of vanin-1 mRNA by low oleic acid concentration; however, lipid accumulation in hepatocytes was not affected at this concentration. As a result of examining with various free fatty acids, it was shown that vanin-1 mRNA was upregulated by the oleic acid and the linoleic acid that makes the lipid droplet easily in the hepatocyte. | |||||
作成日 | ||||||
日付 | 2013-05-31 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 493.47 | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University | |||||
科研費番号 | ||||||
23790799 |