{"_buckets": {"deposit": "eedd4f63-0159-4c1b-843f-97416b78675b"}, "_deposit": {"created_by": 3, "id": "11592", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "11592"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00011592", "sets": ["220"]}, "author_link": ["112198", "112199", "55436"], "item_8_alternative_title_18": {"attribute_name": "別言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Analysis of vanin-1 in non-alcoholic fatty liver disease"}]}, "item_8_alternative_title_19": {"attribute_name": "タイトルよみ", "attribute_value_mlt": [{"subitem_alternative_title": "シンキ シボウカン カンレン ブンシ Vanin-1 ノ キノウ ブンセキ"}]}, "item_8_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2013-05-31"}]}, "item_8_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "2011-2013年度科学研究費助成事業(科学研究費補助金(若手研究(B))研究成果報告書　課題番号：23790799　研究代表者：吉崎隆之(鹿児島大学産学官連携推進センター特任講師)", "subitem_description_type": "Other"}, {"subitem_description": "本研究では高脂肪食を与えたマウス肝臓および培養液に遊離脂肪酸を添加したヒト肝癌由来細胞株のVanin-1 mRNA発現量変化を調べ，そのメカニズムを考察した．動物実験ではVanin-1 mRNAは高脂肪食に替えて僅か1日後には発現が亢進した．培養細胞を使った実験では脂肪滴の形成しない低オレイン酸濃度でもVanin-1 mRNAの発現が亢進した．様々な脂肪酸を用いて検討した結果，肝臓に脂肪滴を作りやすいオレイン酸，リノール酸でVanin-1が発現誘導されることが分かった．", "subitem_description_type": "Other"}, {"subitem_description": "We analyzed the expression of hepatic vanin-1 mRNA following the administration of a high-fat diet in mice as well as free fatty acids in hepatocyte cultures and speculated its possible mechanism. Vanin-1 mRNA levels in the livers of mice were upregulated within a day of the high-fat diet. An in vitro analysis using HuH-7 cells revealed a significant upregulation of vanin-1 mRNA by low oleic acid concentration; however, lipid accumulation in hepatocytes was not affected at this concentration. As a result of examining with various free fatty acids, it was shown that vanin-1 mRNA was upregulated by the oleic acid and the linoleic acid that makes the lipid droplet easily in the hepatocyte.", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者よみ", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "112198", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ヨシザキ, タカユキ"}]}]}, "item_8_full_name_3": {"attribute_name": "別言語の著者", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "112199", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "YOSHIZAKI, Takayuki"}]}]}, "item_8_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "鹿児島大学"}]}, "item_8_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "493.47", "subitem_subject_scheme": "NDC"}]}, "item_8_text_24": {"attribute_name": "公開者よみ", "attribute_value_mlt": [{"subitem_text_value": "カゴシマ ダイガク"}]}, "item_8_text_25": {"attribute_name": "公開者別名", "attribute_value_mlt": [{"subitem_text_value": "Kagoshima University"}]}, "item_8_text_30": {"attribute_name": "NIIタイプ", "attribute_value_mlt": [{"subitem_text_value": "Research Paper"}]}, "item_8_text_41": {"attribute_name": "科研費番号 ", "attribute_value_mlt": [{"subitem_text_value": "23790799"}]}, "item_8_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "吉崎, 隆之"}], "nameIdentifiers": [{"nameIdentifier": "55436", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000070515189", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-10-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "23790799.pdf", "filesize": [{"value": "306.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 306000.0, "url": {"label": "23790799.pdf", "url": "https://ir.kagoshima-u.ac.jp/record/11592/files/23790799.pdf"}, "version_id": "2ef70038-cb14-4e4b-bcef-b887fca336dc"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "新規脂肪肝関連分子Vanin-1の機能解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "新規脂肪肝関連分子Vanin-1の機能解析"}]}, "item_type_id": "8", "owner": "3", "path": ["220"], "permalink_uri": "http://hdl.handle.net/10232/19842", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-10-01"}, "publish_date": "2013-10-01", "publish_status": "0", "recid": "11592", "relation": {}, "relation_version_is_last": true, "title": ["新規脂肪肝関連分子Vanin-1の機能解析"], "weko_shared_id": 3}