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酸化ストレスを抑制するミトコンドリア局在マンガンスーパーオキサイドディスムターゼの機能
http://hdl.handle.net/10232/26738
http://hdl.handle.net/10232/26738b230ae9b-48ba-4c39-95cc-7da6723e910b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
36_p25-33.pdf (1.4 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2016-05-13 | |||||||||
| タイトル | ||||||||||
| タイトル | 酸化ストレスを抑制するミトコンドリア局在マンガンスーパーオキサイドディスムターゼの機能 | |||||||||
| タイトル言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Beyond the function of Manganese superoxide dismutase in oxidative stress | |||||||||
| タイトル言語 | en | |||||||||
| 著者 |
犬童, 寛子
× 犬童, 寛子
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| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Reactive oxygen species (ROS) | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Superoxide | |||||||||
| キーワード | ||||||||||
| 主題言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | MnSOD | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 要約 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | It is well known that reactive oxygen species (ROS) causes various redox related diseases. Recent studies have shown that peroxidant molecules, such as hydrogen peroxide, work actively as signaling molecules in cancer cells. Superoxide is considered to be a major factor in oxidant toxicity, and mitochondria are the major source of superoxide. The reaction of superoxide generated from mitochondria with nitric oxide is faster than superoxide catalyzed reaction, and produces peroxynitrite. Then, peroxynitrite produces hydroxyl radicals and nitrogen dioxide, and oxidizes and nitrates DNAs, lipids and proteins, etc., and induces cell death. Thus, based on research conducted after Fridovich’s seminal studies, we now propose a modified superoxide theory. Manganese superoxide dismutase (MnSOD), which scavenges superoxide anions generated from mitochondria, is an important enzyme in cellular homeostasis, cellular defense and functional dynamics. MnSOD expression and/or activity is generally lower in cancer cells than in their normal cell counterparts, while other studies demonstrate that cancer tissues possess elevated MnSOD expression compared to normal tissues. It suggests that regulation of MnSOD may confer differential outcomes in the protection of normal and cancer cells against agents that cause oxidative stress. Furthermore, expression and/or the activity of MnSOD may affect the antioxidant capacity and overall health of cells by altering mitochondrial metabolism, leading to the development and progression of cancer. It might be suggested that altered MnSOD activity on the mitochondrial metabolism in cancer cells is a key factor of cancer treatment strategy. | |||||||||
| 内容記述言語 | en | |||||||||
| 収録雑誌名 |
ja : 鹿児島大学歯学部紀要 巻 36, p. 25-33, 発行日 2016-03-25 |
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| 作成日 | ||||||||||
| 日付 | 2016-03-25 | |||||||||
| 日付タイプ | Issued | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| ISSN | 03897834 | |||||||||
| NII書誌ID（雑誌） | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| NC ID | AN0035442X | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| NDC | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 491.4 | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | 鹿児島大学 | |||||||||
| 出版者言語 | ja | |||||||||
| 公開者・出版者 | ||||||||||
| 出版者 | Kagoshima University | |||||||||
| 出版者言語 | en | |||||||||
| 備考 | ||||||||||
| 備考 | 欄外タイトル: ミトコンドリア由来活性酸素の役割とその病態 | |||||||||
