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Ghrelin and glucagon-like peptide-2 increase immediately following massive small bowel resection
http://hdl.handle.net/10232/18958
http://hdl.handle.net/10232/1895832230bc7-2141-43ba-9e20-9dca37ed16ce
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0007.pdf (52.6 kB)
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0008.pdf (36.7 kB)
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0010.pdf (357.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-30 | |||||
| タイトル | ||||||
| タイトル | Ghrelin and glucagon-like peptide-2 increase immediately following massive small bowel resection | |||||
| タイトル言語 | en | |||||
| 著者 |
武藤, 充
× 武藤, 充× 加治, 建× 向井, 基× 中目, 和彦× 義岡, 孝子× 谷本, 昭英× 松藤, 凡 |
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| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Acyl ghrelin | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Des-acyl ghrelin | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | GLP-2 | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Adaptation | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Massive small bowel resection | |||||
| キーワード | ||||||
| 主題言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Short bowel syndrome | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 要約 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Children with short bowel syndrome face life-threatening complications. Therefore, there is an urgent need for a new therapy to induce effective adaptation of the remnant intestine. Adaptation occurs only during feeding. We focused on preprandial acyl ghrelin and des-acyl ghrelin, and postprandial glucagon-like peptide-2 (GLP-2), which are known to have active orexigenic and trophic actions. This study aims to clarify the secretion trends of these hormones after massive small bowel resection and to obtain basic data for developing a new treatment. Sixty-three growing male rats were used: 3 were designated as controls receiving no operation and 60 were randomized into the 80% small bowel resection (80% SBR) group and the transection and re-anastomosis group. Changes in body weight, food intake, and remnant intestine morphology were also assessed for 15 days after the operation. Acyl ghrelin and des-acyl ghrelin levels increased immediately, equivalently in both operation groups (P = 0.09 and 0.70). Interestingly, in 80% SBR animals, des-acyl ghrelin peaked on day 1 and acyl ghrelin peaked on day 4 (P = 0.0007 and P = 0.049 vs controls). GLP-2 secretion was obvious in 80% SBR animals (P = 2.25 × 10^{−6}), which increased immediately and peaked on day 4 (P = 0.009 vs. controls). Body weight and food intake in 80% SBR animals recovered to preoperative levels on day 4. Morphological adaptations were evident after day 4. Our results may suggest a management strategy to reinforce these physiological hormone secretion patterns in developing a new therapy for short bowel syndrome. | |||||
| 内容記述言語 | en | |||||
| 収録雑誌名 |
en : Peptides 巻 43, p. 160-166, 発行日 2013-05-01 |
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| 作成日 | ||||||
| 日付 | 2013-05-01 | |||||
| 日付タイプ | Issued | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| ISSN | 01969781 | |||||
| NII書誌ID（雑誌） | ||||||
| 収録物識別子タイプ | NCID | |||||
| NC ID | AA10617807 | |||||
| PubMed Id | ||||||
| 識別子タイプ | PMID | |||||
| PubMed Id | 23517879 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| DOI | https://doi.org/10.1016/j.peptides.2013.03.006 | |||||
| 権利 | ||||||
| 権利情報の言語 | en | |||||
| 権利情報 | Elsevier | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| NDC | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| ファイル（説明） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Table 3, Table 2, Table 1, Figures, Main text, Title page | |||||
| 言語 | en | |||||
| 公開者・出版者 | ||||||
| 出版者 | Elsevier | |||||
| 出版者言語 | en | |||||
